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    Plekhg3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3 [ Mus musculus (house mouse) ]

    Gene ID: 263406, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Plekhg3provided by MGI
    Official Full Name
    pleckstrin homology domain containing, family G (with RhoGef domain) member 3provided by MGI
    Primary source
    MGI:MGI:2388284
    See related
    Ensembl:ENSMUSG00000052609 AllianceGenome:MGI:2388284
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable actin binding activity; guanyl-nucleotide exchange factor activity; and small GTPase binding activity. Predicted to be involved in regulation of cell migration and regulation of establishment of cell polarity. Predicted to be located in cytoplasm and cytoskeleton. Is expressed in several structures, including alimentary system; choroid plexus; early embryo; respiratory system; and sensory organ. Orthologous to human PLEKHG3 (pleckstrin homology and RhoGEF domain containing G3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 15.9), bladder adult (RPKM 13.1) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plekhg3 in Genome Data Viewer
    Location:
    12 C3; 12 33.73 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (76580330..76627265)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (76533303..76580489)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7147 Neighboring gene predicted gene, 40445 Neighboring gene microRNA 5135 Neighboring gene STARR-positive B cell enhancer ABC_E7148 Neighboring gene expressed sequence AI463170 Neighboring gene STARR-seq mESC enhancer starr_32529 Neighboring gene STARR-seq mESC enhancer starr_32530 Neighboring gene STARR-positive B cell enhancer ABC_E8490 Neighboring gene spectrin beta, erythrocytic Neighboring gene STARR-seq mESC enhancer starr_32532 Neighboring gene STARR-seq mESC enhancer starr_32533 Neighboring gene churchill domain containing 1 Neighboring gene glutathione peroxidase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front. Nguyen TT, et al. Proc Natl Acad Sci U S A, 2016 Sep 6. PMID 27555588, Free PMC Article
    2. Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. Dietrich JE, et al. EMBO Rep, 2015 Aug. PMID 26142281, Free PMC Article
    3. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front.
      Title: PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1)  1 citation
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC40768

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of establishment of cell polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family G member 3
    Names
    PH domain-containing family G member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403197.1 → NP_001390126.1  pleckstrin homology domain-containing family G member 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163033
      Related
      ENSMUSP00000151851.2, ENSMUST00000219063.2

    2. NM_001403198.1 → NP_001390127.1  pleckstrin homology domain-containing family G member 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC163033

    3. NM_153804.5 → NP_722499.4  pleckstrin homology domain-containing family G member 3 isoform 2

      See identical proteins and their annotated locations for NP_722499.4

      Status: VALIDATED

      Source sequence(s)
      AC163033
      Consensus CDS
      CCDS25994.1
      UniProtKB/Swiss-Prot
      E9QL46, Q3TSI8, Q4VAC9, Q6A041, Q8BJP5, Q8K0L5, Q8K0T6
      Related
      ENSMUSP00000074729.5, ENSMUST00000075249.6
      Conserved Domains (2) summary
      cd13243
      Location:253 → 396
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00621
      Location:97 → 270
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      76580330..76627265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515870.4 → XP_006515933.1  pleckstrin homology domain-containing family G member 3 isoform X2

      Conserved Domains (2) summary
      smart00325
      Location:118 → 292
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13243
      Location:274 → 417
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

    2. XM_006515880.3 → XP_006515943.1  pleckstrin homology domain-containing family G member 3 isoform X10

      Conserved Domains (2) summary
      smart00325
      Location:118 → 292
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13243
      Location:274 → 417
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

    3. XM_006515869.3 → XP_006515932.1  pleckstrin homology domain-containing family G member 3 isoform X1

      Conserved Domains (2) summary
      smart00325
      Location:118 → 292
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13243
      Location:274 → 417
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

    4. XM_006515878.3 → XP_006515941.1  pleckstrin homology domain-containing family G member 3 isoform X9

      Conserved Domains (2) summary
      smart00325
      Location:118 → 292
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13243
      Location:274 → 417
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

    5. XM_006515876.3 → XP_006515939.1  pleckstrin homology domain-containing family G member 3 isoform X7

      Conserved Domains (2) summary
      smart00325
      Location:118 → 292
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13243
      Location:274 → 417
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

    6. XM_006515877.3 → XP_006515940.1  pleckstrin homology domain-containing family G member 3 isoform X8

      Conserved Domains (2) summary
      smart00325
      Location:118 → 292
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13243
      Location:274 → 417
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

    7. XM_006515871.3 → XP_006515934.1  pleckstrin homology domain-containing family G member 3 isoform X3

      Conserved Domains (2) summary
      smart00325
      Location:118 → 292
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13243
      Location:274 → 417
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

    8. XM_006515872.3 → XP_006515935.1  pleckstrin homology domain-containing family G member 3 isoform X4

      Conserved Domains (2) summary
      smart00325
      Location:118 → 292
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13243
      Location:274 → 417
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

    9. XM_006515874.4 → XP_006515937.1  pleckstrin homology domain-containing family G member 3 isoform X5

      See identical proteins and their annotated locations for XP_006515937.1

      Conserved Domains (2) summary
      smart00325
      Location:97 → 271
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13243
      Location:253 → 396
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4VAC9.2 GenPept UniProtKB/Swiss-Prot:Q4VAC9

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