U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Nuggc nuclear GTPase, germinal center associated [ Mus musculus (house mouse) ]

    Gene ID: 100503545, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Nuggcprovided by MGI
    Official Full Name
    nuclear GTPase, germinal center associatedprovided by MGI
    Primary source
    MGI:MGI:2685446
    See related
    Ensembl:ENSMUSG00000061356 AllianceGenome:MGI:2685446
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm600; SLIP-GC
    Summary
    Predicted to enable GTPase activity. Acts upstream of or within DNA damage response and somatic hypermutation of immunoglobulin genes. Located in nucleus. Orthologous to human NUGGC (nuclear GTPase, germinal center associated). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 1.5), placenta adult (RPKM 0.4) and 2 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Nuggc in Genome Data Viewer
    Location:
    14 D1; 14 34.34 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (65830901..65885893)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (65593499..65648444)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9530047P18 gene Neighboring gene elongator acetyltransferase complex subunit 3 Neighboring gene STARR-seq mESC enhancer starr_36974 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:66211806-66212040 Neighboring gene STARR-seq mESC enhancer starr_36975 Neighboring gene STARR-seq mESC enhancer starr_36976 Neighboring gene STARR-seq mESC enhancer starr_36977 Neighboring gene predicted gene, 30245 Neighboring gene predicted gene, 53863 Neighboring gene scavenger receptor class A, member 5

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein. Richter K, et al. J Biol Chem, 2012 Sep 14. PMID 22833677, Free PMC Article
    2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLIP-GC protects replicating DNA from AID-mediated deamination of cytosines in both strands.
      Title: Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of nuclear cell cycle DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within somatic hypermutation of immunoglobulin genes IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    nuclear GTPase SLIP-GC
    Names
    speckled-like pattern in the germinal center

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195674.2 → NP_001182603.2  nuclear GTPase SLIP-GC

      Status: VALIDATED

      Source sequence(s)
      AC122274
      Consensus CDS
      CCDS56966.1
      UniProtKB/TrEMBL
      D3YY21
      Related
      ENSMUSP00000078434.7, ENSMUST00000079469.7
      Conserved Domains (1) summary
      cl21455
      Location:300 → 466
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      65830901..65885893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518302.2 → XP_006518365.2  nuclear GTPase SLIP-GC isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:128 → 197
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_036158327.1 → XP_036014220.1  nuclear GTPase SLIP-GC isoform X3

      Conserved Domains (1) summary
      cl38936
      Location:128 → 197
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_006518301.3 → XP_006518364.1  nuclear GTPase SLIP-GC isoform X2

      See identical proteins and their annotated locations for XP_006518364.1

      UniProtKB/Swiss-Prot
      D3YWJ0
      Conserved Domains (2) summary
      TIGR03597
      Location:80 → 123
      GTPase_YqeH; ribosome biogenesis GTPase YqeH
      cl38936
      Location:103 → 172
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_006518303.3 → XP_006518366.1  nuclear GTPase SLIP-GC isoform X2

      See identical proteins and their annotated locations for XP_006518366.1

      UniProtKB/Swiss-Prot
      D3YWJ0
      Related
      ENSMUSP00000118402.2, ENSMUST00000150897.8
      Conserved Domains (2) summary
      TIGR03597
      Location:80 → 123
      GTPase_YqeH; ribosome biogenesis GTPase YqeH
      cl38936
      Location:103 → 172
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3YWJ0.1 GenPept UniProtKB/Swiss-Prot:D3YWJ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools