U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Kcnk9 potassium channel, subfamily K, member 9 [ Mus musculus (house mouse) ]

    Gene ID: 223604, updated on 27-Nov-2024

    Summary

    Official Symbol
    Kcnk9provided by MGI
    Official Full Name
    potassium channel, subfamily K, member 9provided by MGI
    Primary source
    MGI:MGI:3521816
    See related
    Ensembl:ENSMUSG00000036760 AllianceGenome:MGI:3521816
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Task3; A930009L07Rik
    Summary
    Enables voltage-gated potassium channel activity. Acts upstream of or within potassium ion import across plasma membrane. Predicted to be located in synaptic vesicle. Predicted to be active in plasma membrane. Is expressed in cerebral cortex; early conceptus; and secondary oocyte. Human ortholog(s) of this gene implicated in Birk-Barel syndrome. Orthologous to human KCNK9 (potassium two pore domain channel subfamily K member 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in adrenal adult (RPKM 23.2), cortex adult (RPKM 9.8) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kcnk9 in Genome Data Viewer
    Location:
    15; 15 D3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (72373722..72422415, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (72501873..72548614, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52221 Neighboring gene predicted gene, 24390 Neighboring gene STARR-positive B cell enhancer ABC_E8594 Neighboring gene STARR-seq mESC enhancer starr_38933 Neighboring gene STARR-seq mESC enhancer starr_38934 Neighboring gene trafficking protein particle complex 9 Neighboring gene predicted gene, 28020 Neighboring gene predicted gene, 53896 Neighboring gene paternally expressed 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables outward rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables outward rectifier potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables outward rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    potassium channel subfamily K member 9
    Names
    TWIK-related acid-sensitive K(+) channel 3
    acid-sensitive potassium channel protein TASK-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033876.2NP_001029048.1  potassium channel subfamily K member 9 precursor

      See identical proteins and their annotated locations for NP_001029048.1

      Status: VALIDATED

      Source sequence(s)
      AC118008, AC161195
      Consensus CDS
      CCDS27515.1
      UniProtKB/Swiss-Prot
      B2RT82, Q3LS21
      Related
      ENSMUSP00000038729.7, ENSMUST00000044624.8
      Conserved Domains (1) summary
      pfam07885
      Location:77132
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      72373722..72422415 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520768.5XP_006520831.1  potassium channel subfamily K member 9 isoform X1

      Conserved Domains (1) summary
      pfam07885
      Location:279334
      Ion_trans_2; Ion channel
    2. XM_036159328.1XP_036015221.1  potassium channel subfamily K member 9 isoform X1

      Conserved Domains (1) summary
      pfam07885
      Location:279334
      Ion_trans_2; Ion channel