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    Tnfrsf17 tumor necrosis factor receptor superfamily, member 17 [ Mus musculus (house mouse) ]

    Gene ID: 21935, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tnfrsf17provided by MGI
    Official Full Name
    tumor necrosis factor receptor superfamily, member 17provided by MGI
    Primary source
    MGI:MGI:1343050
    See related
    Ensembl:ENSMUSG00000022496 AllianceGenome:MGI:1343050
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BCM; BCMA; Tnfrsf13; Tnfrsf13a
    Summary
    Predicted to enable signaling receptor activity. Acts upstream of or within lymphocyte homeostasis. Predicted to be located in membrane. Is expressed in several structures, including hemolymphoid system gland; hippocampus; male reproductive gland or organ; superior cervical ganglion; and urinary system. Human ortholog(s) of this gene implicated in colon carcinoma and multiple myeloma. Orthologous to human TNFRSF17 (TNF receptor superfamily member 17). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in large intestine adult (RPKM 2.7), duodenum adult (RPKM 1.8) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tnfrsf17 in Genome Data Viewer
    Location:
    16 A1; 16 6.42 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (11131131..11137938)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (11313232..11320074)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8617 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:11254345-11254532 Neighboring gene G1 to S phase transition 1 Neighboring gene predicted gene, 57631 Neighboring gene microRNA 1945 Neighboring gene STARR-seq mESC enhancer starr_40101 Neighboring gene STARR-positive B cell enhancer mm9_chr16:11322815-11323116 Neighboring gene sorting nexin 29 Neighboring gene STARR-positive B cell enhancer mm9_chr16:11385888-11386189 Neighboring gene STARR-positive B cell enhancer ABC_E5524 Neighboring gene STARR-positive B cell enhancer ABC_E1181 Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 15 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40106 Neighboring gene tyrosine-protein kinase SgK223 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The characterization of murine BCMA gene defines it as a new member of the tumor necrosis factor receptor superfamily. Madry C, et al. Int Immunol, 1998 Nov. PMID 9846698
    2. B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses. Xu S, et al. Mol Cell Biol, 2001 Jun. PMID 11359913, Free PMC Article
    3. B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells. Yang M, et al. J Immunol, 2005 Sep 1. PMID 16116167
    4. Potent anti-tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma. Oden F, et al. Mol Oncol, 2015 Aug. PMID 25953704, Free PMC Article
    5. [Promoter activity of B-cell maturation antigen gene in mice]. Deng SL, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2008 Aug. PMID 18687216

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. high affinity antibody blocks the binding of the native ligands APRIL and BAFF to BCMA. This finding is rationalized by the high resolution crystal structure of the Fab fragment in complex with the extracellular domain of BCMA
      Title: Potent anti-tumor response by targeting B cell maturation antigen (BCMA) in a mouse model of multiple myeloma.
    2. Elimination of B lymphocyte stimulator receptor 3 (BR-3) and BCMA inhibits the development of SLE in NZM mice.
      Title: Differential Development of Systemic Lupus Erythematosus in NZM 2328 Mice Deficient in Discrete Pairs of BAFF Receptors.
    3. we have identified a novel role for BCMA to control excess BAFF production in murine lupus through restraining the accumulation of BAFF-producing neutrophils.
      Title: Neutrophils contribute to excess serum BAFF levels and promote CD4+ T cell and B cell responses in lupus-prone mice.
    4. Heteromers consisting of one BAFF and two APRIL bind to receptor TACI, BCMA but not to BAFFR.
      Title: Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties.
    5. BCMA is dispensable for the development of SLE in NZM mice. BAFF-BCMA interactions contribute to SLE.
      Title: Development of systemic lupus erythematosus in NZM 2328 mice in the absence of any single BAFF receptor.
    6. Study reveals that BCMA works to control B cell homeostasis and self-tolerance in systemic autoimmunity.
      Title: B cell maturation antigen deficiency exacerbates lymphoproliferation and autoimmunity in murine lupus.
    7. Blimp-1 is a positive regulator of the expression of BCMA gene in mouse plasma cells.
      Title: B-lymphocyte-induced maturation protein1 up-regulates the expression of B-cell maturation antigen in mouse plasma cells.
    8. The 5'-flanking sequence from -820 to +145 bp of BCMA is of promoter activity.
      Title: [Promoter activity of B-cell maturation antigen gene in mice].
    9. Review. Direct BAFF/APRIL signalling in T cells and/or T cell modulation in response to a BAFF-modified B cell compartment may play an important role in inflammation and immunomodulation.
      Title: The role of the BAFF/APRIL system on T cell function.
    10. Review. APRIL interactions with BCMA likely govern memory B cell populations.
      Title: BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lymphocyte homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 17
    Names
    B-cell maturation protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011608.1 → NP_035738.1  tumor necrosis factor receptor superfamily member 17

      See identical proteins and their annotated locations for NP_035738.1

      Status: PROVISIONAL

      Source sequence(s)
      AF061505
      Consensus CDS
      CCDS27962.1
      UniProtKB/Swiss-Prot
      O88472
      Related
      ENSMUSP00000023140.6, ENSMUST00000023140.6
      Conserved Domains (1) summary
      cd13414
      Location:1 → 165
      TNFRSF17; Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA), as well as TNFRSF13A

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      11131131..11137938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521990.4 → XP_006522053.1  tumor necrosis factor receptor superfamily member 17 isoform X2

      Conserved Domains (2) summary
      cd00185
      Location:1 → 18
      TNFRSF; CRD1 [structural motif]
      cl22855
      Location:1 → 112
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    2. XM_006521989.5 → XP_006522052.1  tumor necrosis factor receptor superfamily member 17 isoform X1

      Conserved Domains (1) summary
      cd13414
      Location:1 → 161
      TNFRSF17; Tumor necrosis factor receptor superfamily member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA), as well as TNFRSF13A
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88472.1 GenPept UniProtKB/Swiss-Prot:O88472

    Gene LinkOut

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