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    Senp7 SUMO1/sentrin specific peptidase 7 [ Mus musculus (house mouse) ]

    Gene ID: 66315, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Senp7provided by MGI
    Official Full Name
    SUMO1/sentrin specific peptidase 7provided by MGI
    Primary source
    MGI:MGI:1913565
    See related
    Ensembl:ENSMUSG00000052917 AllianceGenome:MGI:1913565
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410152H17Rik; 2810413I22Rik; 2900036C23Rik; 6030449K19Rik
    Summary
    This gene encodes a SUMO deconjugating enzyme of the Sentrin/SUMO-specific protease (SENP) family. The encoded protein is a protease that exhibits deSUMOylating activity towards proteins involved in chromatin remodeling and promotes chromatin relaxation for DNA repair or transcription. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]
    Expression
    Broad expression in whole brain E14.5 (RPKM 4.4), CNS E18 (RPKM 4.3) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Senp7 in Genome Data Viewer
    Location:
    16 C1.1; 16 33.82 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (55869306..56010394)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (56057526..56190031)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10912 Neighboring gene STARR-positive B cell enhancer ABC_E5549 Neighboring gene PEST proteolytic signal containing nuclear protein Neighboring gene tRNA methyltransferase 10C, mitochondrial RNase P subunit Neighboring gene predicted gene, 22422 Neighboring gene STARR-positive B cell enhancer ABC_E7466 Neighboring gene STARR-positive B cell enhancer ABC_E2467 Neighboring gene STARR-positive B cell enhancer ABC_E7467 Neighboring gene predicted gene, 57818 Neighboring gene STARR-seq mESC enhancer starr_41056 Neighboring gene predicted gene, 41462 Neighboring gene STARR-seq mESC enhancer starr_41058 Neighboring gene mitochondrial ribosomal protein L45 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41059 Neighboring gene STARR-seq mESC enhancer starr_41060 Neighboring gene STARR-seq mESC enhancer starr_41061 Neighboring gene interphotoreceptor matrix proteoglycan 2 Neighboring gene STARR-seq mESC enhancer starr_41062 Neighboring gene STARR-seq mESC enhancer starr_41063 Neighboring gene STARR-seq mESC enhancer starr_41064 Neighboring gene discs, large homolog-associated protein 5 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Emerging roles of desumoylating enzymes. Kim JH, et al. Biochim Biophys Acta, 2009 Mar. PMID 19162180
    2. Maternal SENP7 programs meiosis architecture and embryo survival in mouse. Huang CJ, et al. Biochim Biophys Acta Mol Cell Res, 2017 Jul. PMID 28315713
    3. Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation. Pei J, et al. J Biol Chem, 2024 Jun. PMID 38677512, Free PMC Article
    4. The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin. Maison C, et al. Nat Struct Mol Biol, 2012 Mar 4. PMID 22388734
    5. The Sumo protease Senp7 is required for proper neuronal differentiation. Juarez-Vicente F, et al. Biochim Biophys Acta, 2016 Jul. PMID 27039038

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation.
      Title: Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation.
    2. SENP7 programs zygotic DNA repair and spindle assembly to facilitate maternal-to-zygotic transition. SENP7 intervenes epigenetic scenarios of histone H3 during oocyte and embryo development.
      Title: Maternal SENP7 programs meiosis architecture and embryo survival in mouse.
    3. Senp7 is transiently activated at early stages of neuronal differentiation.
      Title: The Sumo protease Senp7 is required for proper neuronal differentiation.
    4. Depletion of Senp7 delocalizes HP1 alpha from pericentric heterochromatin without affecting H3K9me3 levels.
      Title: The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO-specific endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO-specific endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein desumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein desumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sentrin-specific protease 7
    Names
    SUMO-1-specific protease 2
    SUMO1/sentrin specific protease 7
    sentrin/SUMO-specific protease SENP7
    NP_001003972.1
    NP_001003973.1
    NP_001291432.1
    NP_001347002.1
    NP_079759.2
    XP_006522514.1
    XP_006522515.1
    XP_006522517.1
    XP_006522518.1
    XP_017172600.1
    XP_030105091.1
    XP_030105092.1
    XP_036015979.1
    XP_036015980.1
    XP_036015981.1
    XP_036015982.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003972.2 → NP_001003972.1  sentrin-specific protease 7 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK012740, AK040314, CN692265
      Consensus CDS
      CCDS28223.1
      UniProtKB/TrEMBL
      Q9CQN9
      Related
      ENSMUSP00000043023.6, ENSMUST00000049128.11

    2. NM_001003973.2 → NP_001003973.1  sentrin-specific protease 7 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK020068, AK040314, CN692265
      Consensus CDS
      CCDS88943.1
      UniProtKB/TrEMBL
      Q9CRF0, Q9CX65
      Related
      ENSMUSP00000156009.2, ENSMUST00000201011.2

    3. NM_001304503.1 → NP_001291432.1  sentrin-specific protease 7 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 5 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154275, AK164354, AV331650
      Consensus CDS
      CCDS84243.1
      UniProtKB/TrEMBL
      A0A0J9YUC9, Q3TPI1
      Related
      ENSMUSP00000144116.2, ENSMUST00000202000.2

    4. NM_001360073.1 → NP_001347002.1  sentrin-specific protease 7 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. The encoded isoform (6) is shorter, compared to isoform 1.
      Source sequence(s)
      AC154275, AC171202
      Conserved Domains (1) summary
      COG5160
      Location:677 → 967
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    5. NM_025483.4 → NP_079759.2  sentrin-specific protease 7 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC154275, AK040314, AK085060
      Consensus CDS
      CCDS28222.1
      UniProtKB/Swiss-Prot
      Q6P398, Q80TA3, Q8BUH8
      Related
      ENSMUSP00000086779.3, ENSMUST00000089362.9
      Conserved Domains (1) summary
      COG5160
      Location:743 → 1033
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      55869306..56010394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160087.1 → XP_036015980.1  sentrin-specific protease 7 isoform X3

      UniProtKB/TrEMBL
      E9Q1L5
      Conserved Domains (1) summary
      COG5160
      Location:716 → 1006
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    2. XM_030249232.2 → XP_030105092.1  sentrin-specific protease 7 isoform X10

      UniProtKB/TrEMBL
      Q9CQN9

    3. XM_036160086.1 → XP_036015979.1  sentrin-specific protease 7 isoform X1

      UniProtKB/Swiss-Prot
      Q6P398, Q80TA3, Q8BUH8
      Conserved Domains (1) summary
      COG5160
      Location:743 → 1033
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    4. XM_006522451.5 → XP_006522514.1  sentrin-specific protease 7 isoform X2

      Conserved Domains (1) summary
      COG5160
      Location:743 → 1010
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    5. XM_006522452.5 → XP_006522515.1  sentrin-specific protease 7 isoform X4

      Conserved Domains (1) summary
      COG5160
      Location:679 → 969
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    6. XM_006522455.5 → XP_006522518.1  sentrin-specific protease 7 isoform X8

      Conserved Domains (1) summary
      COG5160
      Location:613 → 903
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    7. XM_017317111.3 → XP_017172600.1  sentrin-specific protease 7 isoform X3

      UniProtKB/TrEMBL
      E9Q1L5
      Related
      ENSMUSP00000086776.4, ENSMUST00000089360.10
      Conserved Domains (1) summary
      COG5160
      Location:716 → 1006
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    8. XM_036160089.1 → XP_036015982.1  sentrin-specific protease 7 isoform X6

      Conserved Domains (1) summary
      COG5160
      Location:652 → 942
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    9. XM_006522454.5 → XP_006522517.1  sentrin-specific protease 7 isoform X7

      Conserved Domains (1) summary
      COG5160
      Location:650 → 940
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    10. XM_030249231.2 → XP_030105091.1  sentrin-specific protease 7 isoform X9

      Conserved Domains (1) summary
      COG5160
      Location:586 → 876
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    11. XM_036160088.1 → XP_036015981.1  sentrin-specific protease 7 isoform X5

      Conserved Domains (1) summary
      COG5160
      Location:677 → 967
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    RNA

    1. XR_003951814.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001003971.1: Suppressed sequence

      Description
      NM_001003971.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BUH8.1 GenPept UniProtKB/Swiss-Prot:Q8BUH8

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