Bag6 BCL2-associated athanogene 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bag6provided by MGI
Official Full Name: BCL2-associated athanogene 6provided by MGI
Primary source: MGI:MGI:1919439
See related: Ensembl:ENSMUSG00000024392 AllianceGenome:MGI:1919439
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: G3; Bat3; BAG-6; Scythe; D17H6S52E; 2410045D21Rik
Summary: Enables Hsp70 protein binding activity; polyubiquitin modification-dependent protein binding activity; and proteasome binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; protein stabilization; and synaptonemal complex assembly. Acts upstream of or within negative regulation of apoptotic process. Located in cytosol and nucleus. Is expressed in palatal shelf epithelium. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human BAG6 (BAG cochaperone 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 225.5), adrenal adult (RPKM 122.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 18.59 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (35354132..35366297)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (35135156..35147321)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells.
Title: BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells.
Differential lung gene expression identified Zscan2 and Bag6 as novel tissue repair players in an experimental COPD model.
Title: Differential lung gene expression identified Zscan2 and Bag6 as novel tissue repair players in an experimental COPD model.
BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly.
Title: BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly.
BAG6 negatively regulates the RLR signaling pathway by targeting VISA/MAVS.
Title: BAG6 negatively regulates the RLR signaling pathway by targeting VISA/MAVS.
BCL2-associated athanogene 6 exon24 contributes to testosterone synthesis and male fertility in mammals.
Title: BCL2-associated athanogene 6 exon24 contributes to testosterone synthesis and male fertility in mammals.
Down-regulation of HLA-B-associated transcript 3 impairs the tumoricidal effect of natural killer cells through promoting the T cell immunoglobulin and mucin domain-containing-3 signaling in a mouse head and neck squamous cell carcinoma model.
Title: Down-regulation of HLA-B-associated transcript 3 impairs the tumoricidal effect of natural killer cells through promoting the T cell immunoglobulin and mucin domain-containing-3 signaling in a mouse head and neck squamous cell carcinoma model.
Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function.
Title: Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function.
BAG6 contributes to glucose uptake by supporting the cell surface translocation of the glucose transporter GLUT4.
Title: BAG6 contributes to glucose uptake by supporting the cell surface translocation of the glucose transporter GLUT4.
The cleft palate candidate gene BAG6 supports FoxO1 acetylation topromote FasL-mediated apoptosis during palate fusion.
Title: The cleft palate candidate gene BAG6 supports FoxO1 acetylation to promote FasL-mediated apoptosis during palate fusion.
BAT3 negatively regulates lipopolysaccharide-induced NF-kappaB signaling through TRAF6.
Title: BAT3 negatively regulates lipopolysaccharide-induced NF-κB signaling through TRAF6.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

2410045D21Rik (e-PCR), detects polymorphism
- UniSTS:142119

NoName (e-PCR)
- UniSTS:237631

RH126866 (e-PCR)
- UniSTS:209300

MARC_5411-5412:996690356:1 (e-PCR)
- UniSTS:269505

AA900379 (e-PCR)
- UniSTS:248821

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables misfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables misfolded protein binding	IEA Inferred from Electronic Annotation more info
enables misfolded protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables polyubiquitin modification-dependent protein binding	IDA Inferred from Direct Assay more info	PubMed
enables proteasome binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IEA Inferred from Electronic Annotation more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-specific protease binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-specific protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in ERAD pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in NK T cell activation	IEA Inferred from Electronic Annotation more info
involved_in antigen processing and presentation of peptide antigen via MHC class I	TAS Traceable Author Statement more info	PubMed
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within apoptotic process	RCA inferred from Reviewed Computational Analysis more info	PubMed
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum stress-induced pre-emptive quality control	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum stress-induced pre-emptive quality control	ISS Inferred from Sequence or Structural Similarity more info
involved_in immune response-activating cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in immune response-activating cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in internal peptidyl-lysine acetylation	ISO Inferred from Sequence Orthology more info
involved_in internal peptidyl-lysine acetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of unfolded protein	IEA Inferred from Electronic Annotation more info
involved_in maintenance of unfolded protein	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell activation	IEA Inferred from Electronic Annotation more info
involved_in natural killer cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERAD pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein targeting to endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
involved_in proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasomal protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of apoptotic process	RCA inferred from Reviewed Computational Analysis more info	PubMed
involved_in regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptonemal complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tail-anchored membrane protein insertion into ER membrane	ISO Inferred from Sequence Orthology more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of BAT3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of BAT3 complex	ISO Inferred from Sequence Orthology more info
part_of BAT3 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: large proline-rich protein BAG6

Names: BAG family molecular chaperone regulator 6; HLA-B-associated transcript 3; large proline-rich protein BAT3; protein Scythe

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252468.2 → NP_001239397.1 large proline-rich protein BAG6 isoform 2

Status: VALIDATED

Source sequence(s)

CR974444

Consensus CDS

CCDS57073.1

UniProtKB/TrEMBL

G3UYQ2, Q3UF95

Related

ENSMUSP00000129324.3, ENSMUST00000166426.9

Conserved Domains (3) summary

PRK07764
Location:909 → 1100

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:260 → 374

DUF3538; Domain of unknown function (DUF3538)
NM_001252469.2 → NP_001239398.1 large proline-rich protein BAG6 isoform 3

Status: VALIDATED

Source sequence(s)

CR974444

Consensus CDS

CCDS57072.1

UniProtKB/TrEMBL

G3UYQ2, G3UZT6

Related

ENSMUSP00000134628.2, ENSMUST00000173550.8

Conserved Domains (3) summary

PRK07764
Location:944 → 1122

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:260 → 374

DUF3538; Domain of unknown function (DUF3538)
NM_001372260.1 → NP_001359189.1 large proline-rich protein BAG6 isoform 4

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4

Conserved Domains (3) summary

PRK07764
Location:963 → 1154

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
NM_001372261.1 → NP_001359190.1 large proline-rich protein BAG6 isoform 5

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4

Conserved Domains (3) summary

PRK07764
Location:962 → 1153

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
NM_001372262.1 → NP_001359191.1 large proline-rich protein BAG6 isoform 6

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:945 → 1136

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:260 → 374

DUF3538; Domain of unknown function (DUF3538)
NM_001372265.1 → NP_001359194.1 large proline-rich protein BAG6 isoform 7

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:927 → 1147

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
NM_001372266.1 → NP_001359195.1 large proline-rich protein BAG6 isoform 12

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:927 → 1105

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
NM_001372267.1 → NP_001359196.1 large proline-rich protein BAG6 isoform 1

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/Swiss-Prot

Q8SNA3, Q9Z1R2

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:927 → 1118

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
NM_001372268.1 → NP_001359197.1 large proline-rich protein BAG6 isoform 1

Status: VALIDATED

Source sequence(s)

CR974444

Consensus CDS

CCDS28688.1

UniProtKB/Swiss-Prot

Q8SNA3, Q9Z1R2

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:927 → 1118

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
NM_001372269.1 → NP_001359198.1 large proline-rich protein BAG6 isoform 18

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:926 → 1117

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
NM_001372270.1 → NP_001359199.1 large proline-rich protein BAG6 isoform 18

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:926 → 1117

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
NM_001372271.1 → NP_001359200.1 large proline-rich protein BAG6 isoform 18

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:926 → 1117

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
NM_001372272.1 → NP_001359201.1 large proline-rich protein BAG6 isoform 18

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:926 → 1117

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
NM_001372273.1 → NP_001359202.1 large proline-rich protein BAG6 isoform 8

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:926 → 1146

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
NM_001372274.1 → NP_001359203.1 large proline-rich protein BAG6 isoform 8

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:926 → 1146

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
NM_001372275.1 → NP_001359204.1 large proline-rich protein BAG6 isoform 9

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4

Conserved Domains (3) summary

PRK07764
Location:963 → 1141

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
NM_001372276.1 → NP_001359205.1 large proline-rich protein BAG6 isoform 10

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4

Conserved Domains (3) summary

PRK07764
Location:962 → 1140

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
NM_001372277.1 → NP_001359206.1 large proline-rich protein BAG6 isoform 10

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4

Related

ENSMUSP00000134425.2, ENSMUST00000174281.9

Conserved Domains (3) summary

PRK07764
Location:962 → 1140

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
NM_001372278.1 → NP_001359207.1 large proline-rich protein BAG6 isoform 10

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4

Conserved Domains (3) summary

PRK07764
Location:962 → 1140

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
NM_001372279.1 → NP_001359208.1 large proline-rich protein BAG6 isoform 2

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

G3UYQ2, Q3UF95

Conserved Domains (3) summary

PRK07764
Location:909 → 1100

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:260 → 374

DUF3538; Domain of unknown function (DUF3538)
NM_001372280.1 → NP_001359209.1 large proline-rich protein BAG6 isoform 11

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:908 → 1099

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:260 → 374

DUF3538; Domain of unknown function (DUF3538)
NM_001372281.1 → NP_001359210.1 large proline-rich protein BAG6 isoform 11

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:908 → 1099

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:260 → 374

DUF3538; Domain of unknown function (DUF3538)
NM_001372282.1 → NP_001359211.1 large proline-rich protein BAG6 isoform 11

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:908 → 1099

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:260 → 374

DUF3538; Domain of unknown function (DUF3538)
NM_001372283.1 → NP_001359212.1 large proline-rich protein BAG6 isoform 3

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

G3UYQ2, G3UZT6

Conserved Domains (3) summary

PRK07764
Location:944 → 1122

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:260 → 374

DUF3538; Domain of unknown function (DUF3538)
NM_001372284.1 → NP_001359213.1 large proline-rich protein BAG6 isoform 12

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:927 → 1105

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
NM_001372285.1 → NP_001359214.1 large proline-rich protein BAG6 isoform 12

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:927 → 1105

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
NM_001372286.1 → NP_001359215.1 large proline-rich protein BAG6 isoform 13

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:926 → 1104

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
NM_001372287.1 → NP_001359216.1 large proline-rich protein BAG6 isoform 13

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:926 → 1104

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
NM_001372288.1 → NP_001359217.1 large proline-rich protein BAG6 isoform 14

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:926 → 1064

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
NM_001372289.1 → NP_001359218.1 large proline-rich protein BAG6 isoform 15

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:908 → 1086

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:260 → 374

DUF3538; Domain of unknown function (DUF3538)
NM_001372290.1 → NP_001359219.1 large proline-rich protein BAG6 isoform 15

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

G3UYQ2

Related

ENSMUSP00000134175.2, ENSMUST00000172571.8

Conserved Domains (3) summary

PRK07764
Location:908 → 1086

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:260 → 374

DUF3538; Domain of unknown function (DUF3538)
NM_001372291.1 → NP_001359220.1 large proline-rich protein BAG6 isoform 16

Status: VALIDATED

Source sequence(s)

CR974444

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:901 → 1079

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
NM_001404327.1 → NP_001391256.1 large proline-rich protein BAG6 isoform 4

Status: VALIDATED

Source sequence(s)

CR974444
NM_001404328.1 → NP_001391257.1 large proline-rich protein BAG6 isoform 5

Status: VALIDATED

Source sequence(s)

CR974444
NM_001404329.1 → NP_001391258.1 large proline-rich protein BAG6 isoform 5

Status: VALIDATED

Source sequence(s)

CR974444
NM_001404330.1 → NP_001391259.1 large proline-rich protein BAG6 isoform 17

Status: VALIDATED

Source sequence(s)

CR974444
NM_001404331.1 → NP_001391260.1 large proline-rich protein BAG6 isoform 9

Status: VALIDATED

Source sequence(s)

CR974444
NM_057171.3 → NP_476512.1 large proline-rich protein BAG6 isoform 1

Status: VALIDATED

Source sequence(s)

CR974444

Consensus CDS

CCDS28688.1

UniProtKB/Swiss-Prot

Q8SNA3, Q9Z1R2

UniProtKB/TrEMBL

G3UYQ2

Related

ENSMUSP00000025250.8, ENSMUST00000025250.14

Conserved Domains (3) summary

PRK07764
Location:927 → 1118

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

35354132..35366297

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524117.4 → XP_006524180.1 large proline-rich protein BAG6 isoform X9

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:945 → 1136

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:260 → 374

DUF3538; Domain of unknown function (DUF3538)
XM_030249713.1 → XP_030105573.1 large proline-rich protein BAG6 isoform X10

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:944 → 1135

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:260 → 374

DUF3538; Domain of unknown function (DUF3538)
XM_006524118.4 → XP_006524181.1 large proline-rich protein BAG6 isoform X14

UniProtKB/TrEMBL

A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4

Conserved Domains (3) summary

PRK07764
Location:1004 → 1195

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:58 → 128

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:319 → 433

DUF3538; Domain of unknown function (DUF3538)
XM_006524115.3 → XP_006524178.1 large proline-rich protein BAG6 isoform X7

UniProtKB/TrEMBL

A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4

Conserved Domains (3) summary

PRK07764
Location:1004 → 1182

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:58 → 128

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:319 → 433

DUF3538; Domain of unknown function (DUF3538)
XM_017317432.2 → XP_017172921.1 large proline-rich protein BAG6 isoform X1

UniProtKB/TrEMBL

A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4

Conserved Domains (3) summary

PRK07764
Location:1004 → 1224

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:58 → 128

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:319 → 433

DUF3538; Domain of unknown function (DUF3538)
XM_017317434.2 → XP_017172923.1 large proline-rich protein BAG6 isoform X8

UniProtKB/TrEMBL

A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4

Conserved Domains (3) summary

PRK07764
Location:1004 → 1142

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:58 → 128

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:319 → 433

DUF3538; Domain of unknown function (DUF3538)
XM_036160539.1 → XP_036016432.1 large proline-rich protein BAG6 isoform X2

UniProtKB/TrEMBL

A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4

Conserved Domains (3) summary

PRK07764
Location:1003 → 1223

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:58 → 128

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:319 → 433

DUF3538; Domain of unknown function (DUF3538)
XM_036160541.1 → XP_036016434.1 large proline-rich protein BAG6 isoform X6

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:968 → 1188

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:58 → 128

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:319 → 433

DUF3538; Domain of unknown function (DUF3538)
XM_030249721.1 → XP_030105581.1 large proline-rich protein BAG6 isoform X13

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:968 → 1106

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:58 → 128

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:319 → 433

DUF3538; Domain of unknown function (DUF3538)
XM_030249712.2 → XP_030105572.1 large proline-rich protein BAG6 isoform X3

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:985 → 1176

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:58 → 128

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:301 → 415

DUF3538; Domain of unknown function (DUF3538)
XM_030249715.2 → XP_030105575.1 large proline-rich protein BAG6 isoform X11

UniProtKB/Swiss-Prot

Q8SNA3, Q9Z1R2

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:927 → 1118

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
XM_006524113.4 → XP_006524176.1 large proline-rich protein BAG6 isoform X4

UniProtKB/TrEMBL

A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4

Conserved Domains (3) summary

PRK07764
Location:963 → 1154

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:278 → 392

DUF3538; Domain of unknown function (DUF3538)
XM_030249711.1 → XP_030105571.1 large proline-rich protein BAG6 isoform X9

UniProtKB/TrEMBL

G3UYQ2

Conserved Domains (3) summary

PRK07764
Location:945 → 1136

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01809
Location:17 → 87

Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins

pfam12057
Location:260 → 374

DUF3538; Domain of unknown function (DUF3538)