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    Arhgef33 Rho guanine nucleotide exchange factor 33 [ Mus musculus (house mouse) ]

    Gene ID: 381112, updated on 27-Nov-2024

    Summary

    Official Symbol
    Arhgef33provided by MGI
    Official Full Name
    Rho guanine nucleotide exchange factor 33provided by MGI
    Primary source
    MGI:MGI:2685787
    See related
    Ensembl:ENSMUSG00000054901 AllianceGenome:MGI:2685787
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm941
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Orthologous to human ARHGEF33 (Rho guanine nucleotide exchange factor 33). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 8.0) and testis adult (RPKM 1.4) See more
    Orthologs
    NEW
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    Genomic context

    See Arhgef33 in Genome Data Viewer
    Location:
    17 E3; 17 50.63 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (80614354..80740926)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (80306923..80433497)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43307 Neighboring gene STARR-seq mESC enhancer starr_43308 Neighboring gene DExH-box helicase 57 Neighboring gene STARR-positive B cell enhancer ABC_E7560 Neighboring gene MORN repeat containing 2 Neighboring gene STARR-seq mESC enhancer starr_43309 Neighboring gene STARR-seq mESC enhancer starr_43310 Neighboring gene predicted gene 10190 Neighboring gene STARR-seq mESC enhancer starr_43312 Neighboring gene SOS Ras/Rac guanine nucleotide exchange factor 1 Neighboring gene STARR-seq mESC enhancer starr_43313 Neighboring gene STARR-positive B cell enhancer ABC_E8924 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene alkaline phosphatase, intestinal pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    rho guanine nucleotide exchange factor 33
    Names
    DH and coiled-coil domain-containing protein ENSP00000381780 homolog
    Rho guanine nucleotide exchange factor (GEF) 33

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145452.1NP_001138924.1  rho guanine nucleotide exchange factor 33

      See identical proteins and their annotated locations for NP_001138924.1

      Status: PROVISIONAL

      Source sequence(s)
      AC161447, AI848431, AK053944, BB628974, BE653884, BE654086, BE950677, CK793318, CK793330
      Consensus CDS
      CCDS50189.1
      UniProtKB/Swiss-Prot
      Q8BW86
      Related
      ENSMUSP00000063284.6, ENSMUST00000068175.6
      Conserved Domains (1) summary
      cl02571
      Location:277444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      80614354..80740926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524512.5XP_006524575.1  rho guanine nucleotide exchange factor 33 isoform X3

      Conserved Domains (2) summary
      pfam07111
      Location:42127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:259426
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    2. XM_030249876.2XP_030105736.1  rho guanine nucleotide exchange factor 33 isoform X4

      Conserved Domains (2) summary
      pfam07111
      Location:42127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:259426
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    3. XM_030249875.2XP_030105735.1  rho guanine nucleotide exchange factor 33 isoform X3

      Conserved Domains (2) summary
      pfam07111
      Location:42127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:259426
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    4. XM_006524509.4XP_006524572.1  rho guanine nucleotide exchange factor 33 isoform X1

      See identical proteins and their annotated locations for XP_006524572.1

      Conserved Domains (2) summary
      pfam07111
      Location:42127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    5. XM_006524511.4XP_006524574.1  rho guanine nucleotide exchange factor 33 isoform X2

      Conserved Domains (2) summary
      pfam07111
      Location:42127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    6. XM_006524510.4XP_006524573.1  rho guanine nucleotide exchange factor 33 isoform X1

      See identical proteins and their annotated locations for XP_006524573.1

      Conserved Domains (2) summary
      pfam07111
      Location:42127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    7. XM_006524514.5XP_006524577.1  rho guanine nucleotide exchange factor 33 isoform X7

      Conserved Domains (2) summary
      pfam07111
      Location:42127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    8. XM_006524515.5XP_006524578.1  rho guanine nucleotide exchange factor 33 isoform X8

      Conserved Domains (2) summary
      pfam07111
      Location:42127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    9. XM_030249880.2XP_030105740.1  rho guanine nucleotide exchange factor 33 isoform X9

      Conserved Domains (2) summary
      pfam07111
      Location:42127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    10. XM_006524516.5XP_006524579.1  rho guanine nucleotide exchange factor 33 isoform X9

      Conserved Domains (2) summary
      pfam07111
      Location:42127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    11. XM_006524519.5XP_006524582.1  rho guanine nucleotide exchange factor 33 isoform X10

      See identical proteins and their annotated locations for XP_006524582.1

      Conserved Domains (2) summary
      pfam07111
      Location:42127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    12. XM_006524518.5XP_006524581.1  rho guanine nucleotide exchange factor 33 isoform X10

      See identical proteins and their annotated locations for XP_006524581.1

      Conserved Domains (2) summary
      pfam07111
      Location:42127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    13. XM_006524513.5XP_006524576.1  rho guanine nucleotide exchange factor 33 isoform X5

      Conserved Domains (2) summary
      pfam07111
      Location:42127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    14. XM_017317545.3XP_017173034.1  rho guanine nucleotide exchange factor 33 isoform X11

      UniProtKB/Swiss-Prot
      Q8BW86
      Conserved Domains (1) summary
      cl02571
      Location:277444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    15. XM_030249877.2XP_030105737.1  rho guanine nucleotide exchange factor 33 isoform X6

      Conserved Domains (2) summary
      pfam07111
      Location:42127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    16. XM_030249879.2XP_030105739.1  rho guanine nucleotide exchange factor 33 isoform X6

      Conserved Domains (2) summary
      pfam07111
      Location:42127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    17. XM_006524523.5XP_006524586.1  rho guanine nucleotide exchange factor 33 isoform X11

      See identical proteins and their annotated locations for XP_006524586.1

      UniProtKB/Swiss-Prot
      Q8BW86
      Conserved Domains (1) summary
      cl02571
      Location:277444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    18. XM_006524520.5XP_006524583.1  rho guanine nucleotide exchange factor 33 isoform X10

      See identical proteins and their annotated locations for XP_006524583.1

      Conserved Domains (2) summary
      pfam07111
      Location:42127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    19. XM_006524524.5XP_006524587.1  rho guanine nucleotide exchange factor 33 isoform X11

      See identical proteins and their annotated locations for XP_006524587.1

      UniProtKB/Swiss-Prot
      Q8BW86
      Conserved Domains (1) summary
      cl02571
      Location:277444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    20. XM_006524522.5XP_006524585.1  rho guanine nucleotide exchange factor 33 isoform X12

      Conserved Domains (2) summary
      pfam07111
      Location:42127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    21. XM_011246520.4XP_011244822.1  rho guanine nucleotide exchange factor 33 isoform X13

      Conserved Domains (2) summary
      pfam07111
      Location:42127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    22. XM_006524525.5XP_006524588.1  rho guanine nucleotide exchange factor 33 isoform X14

      Conserved Domains (2) summary
      pfam07111
      Location:42127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    23. XM_030249883.2XP_030105743.1  rho guanine nucleotide exchange factor 33 isoform X15

      Conserved Domains (2) summary
      pfam07111
      Location:42127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.