Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc3a2provided by MGI
Official Full Name: solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2provided by MGI
Primary source: MGI:MGI:96955
See related: Ensembl:ENSMUSG00000010095 AllianceGenome:MGI:96955
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4F2; Cd98; Ly10; Mdu1; 4F2HC; Ly-10; NACAE; Ly-m10; Mgp-2hc
Summary: Enables protein homodimerization activity. Involved in L-leucine transport. Located in apical pole of neuron and plasma membrane. Is active in synapse. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human SLC3A2 (solute carrier family 3 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 55.8), genital fat pad adult (RPKM 41.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 5.44 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (8684931..8700733, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (8706882..8723369, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation.
Title: Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation.
Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular endothelial ferroptosis and aggravates atherosclerosis progression in ApoE[-/-]mice.
Title: Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular endothelial ferroptosis and aggravates atherosclerosis progression in ApoE(-/-)mice.
Screening of ferroptosis-related genes in sepsis-induced liver failure and analysis of immune correlation.
Title: Screening of ferroptosis-related genes in sepsis-induced liver failure and analysis of immune correlation.
Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer's Disease.
Title: Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer's Disease.
SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced Adipocyte Differentiation.
Title: SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced Adipocyte Differentiation.
Galectin-3 enhances atrial remodelling and arrhythmogenesis through CD98 signalling.
Title: Galectin-3 enhances atrial remodelling and arrhythmogenesis through CD98 signalling.
CD98-induced CD147 signaling stabilizes the Foxp3 protein to maintain tissue homeostasis.
Title: CD98-induced CD147 signaling stabilizes the Foxp3 protein to maintain tissue homeostasis.
SLC3A2 inhibits ferroptosis in laryngeal carcinoma via mTOR pathway.
Title: SLC3A2 inhibits ferroptosis in laryngeal carcinoma via mTOR pathway.
Metabolic adaptations to hypoxia in the neonatal mouse forebrain can occur independently of the transporters SLC7A5 and SLC3A2.
Title: Metabolic adaptations to hypoxia in the neonatal mouse forebrain can occur independently of the transporters SLC7A5 and SLC3A2.
Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice.
Title: Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

X14309 (e-PCR)
- UniSTS:181196

AI314110 (e-PCR)
- UniSTS:181197

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-alanine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-alanine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-alanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-leucine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-leucine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-leucine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables aromatic amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables aromatic amino acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables aromatic amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info	PubMed
enables exogenous protein binding	IEA Inferred from Electronic Annotation more info
enables exogenous protein binding	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid secondary active transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in L-alanine import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-alanine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-alanine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-histidine transport	IEA Inferred from Electronic Annotation more info
involved_in L-histidine transport	ISO Inferred from Sequence Orthology more info
involved_in L-leucine import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-leucine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-leucine import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in L-leucine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-leucine transport	ISO Inferred from Sequence Orthology more info
involved_in L-leucine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in isoleucine transport	IEA Inferred from Electronic Annotation more info
involved_in isoleucine transport	ISO Inferred from Sequence Orthology more info
involved_in methionine transport	IEA Inferred from Electronic Annotation more info
involved_in methionine transport	ISO Inferred from Sequence Orthology more info
involved_in neutral amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in phenylalanine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phenylalanine transport	IEA Inferred from Electronic Annotation more info
involved_in phenylalanine transport	ISO Inferred from Sequence Orthology more info
involved_in proline transport	IEA Inferred from Electronic Annotation more info
involved_in proline transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to exogenous dsRNA	ISO Inferred from Sequence Orthology more info	PubMed
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info
involved_in symbiont entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone transport	IEA Inferred from Electronic Annotation more info
involved_in thyroid hormone transport	ISO Inferred from Sequence Orthology more info
involved_in tryptophan transport	ISO Inferred from Sequence Orthology more info
involved_in tryptophan transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in tyrosine transport	IEA Inferred from Electronic Annotation more info
involved_in tyrosine transport	ISO Inferred from Sequence Orthology more info
involved_in valine transport	IEA Inferred from Electronic Annotation more info
involved_in valine transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of amino acid transport complex	IEA Inferred from Electronic Annotation more info
part_of amino acid transport complex	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical pole of neuron	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: amino acid transporter heavy chain SLC3A2

Names: 4F2 cell-surface antigen heavy chain; CD98 antigen; CD98 heavy chain; antigen identified by monoclonal antibodies 4F2; solute carrier family 3 member 2; type II transmembrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161413.2 → NP_001154885.1 amino acid transporter heavy chain SLC3A2 isoform a

See identical proteins and their annotated locations for NP_001154885.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (a).

Source sequence(s)

AC025794

Consensus CDS

CCDS50381.1

UniProtKB/TrEMBL

Q3TN39

Related

ENSMUSP00000130194.2, ENSMUST00000170157.8

Conserved Domains (3) summary

COG0366
Location:169 → 513

AmyA; Glycosidase [Carbohydrate transport and metabolism]

pfam16028
Location:85 → 156

SLC3A2_N; Solute carrier family 3 member 2 N-terminus

cl07893
Location:139 → 468

AmyAc_family; Alpha amylase catalytic domain family
NM_001410771.1 → NP_001397700.1 amino acid transporter heavy chain SLC3A2 isoform b

Status: VALIDATED

Source sequence(s)

AC025794

UniProtKB/Swiss-Prot

G3UWA6, P10852, Q54AH5
NM_008577.5 → NP_032603.3 amino acid transporter heavy chain SLC3A2 isoform b

See identical proteins and their annotated locations for NP_032603.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' coding region and 5' UTR, compared to variant 1. This results in a shorter and distinct N-terminus in isoform b, compared to isoform a.

Source sequence(s)

AC025794

Consensus CDS

CCDS29540.1

UniProtKB/Swiss-Prot

G3UWA6, P10852, Q54AH5

UniProtKB/TrEMBL

Q3TN39

Related

ENSMUSP00000010239.5, ENSMUST00000010239.6

Conserved Domains (2) summary

pfam16028
Location:45 → 118

SLC3A2_N; Solute carrier family 3 member 2 N-terminus

cl38930
Location:100 → 429

AmyAc_family; Alpha amylase catalytic domain family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

8684931..8700733 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318078.3 → XP_017173567.1 amino acid transporter heavy chain SLC3A2 isoform X1

UniProtKB/Swiss-Prot

G3UWA6, P10852, Q54AH5

UniProtKB/TrEMBL

Q3TN39

Conserved Domains (2) summary

pfam16028
Location:45 → 118

SLC3A2_N; Solute carrier family 3 member 2 N-terminus

cl38930
Location:100 → 429

AmyAc_family; Alpha amylase catalytic domain family
XM_006526733.4 → XP_006526796.1 amino acid transporter heavy chain SLC3A2 isoform X2

UniProtKB/TrEMBL

A0A0U1RPK4

Related

ENSMUSP00000146016.2, ENSMUST00000206598.2

Conserved Domains (2) summary

TIGR02403
Location:179 → 297

trehalose_treC; alpha,alpha-phosphotrehalase

cl38930
Location:1 → 206

AmyAc_family; Alpha amylase catalytic domain family