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    Klhl15 kelch-like 15 [ Mus musculus (house mouse) ]

    Gene ID: 236904, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Klhl15provided by MGI
    Official Full Name
    kelch-like 15provided by MGI
    Primary source
    MGI:MGI:1923400
    See related
    Ensembl:ENSMUSG00000043929 AllianceGenome:MGI:1923400
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330500C13Rik
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in negative regulation of double-strand break repair via homologous recombination and nuclear protein quality control by the ubiquitin-proteasome system. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 103. Orthologous to human KLHL15 (kelch like family member 15). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Klhl15 in Genome Data Viewer
    Location:
    X C3; X 41.53 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (93275884..93321330)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (94232278..94277724)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene zinc finger protein X-linked Neighboring gene predicted gene, 46691 Neighboring gene STARR-seq mESC enhancer starr_47557 Neighboring gene eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked Neighboring gene STARR-seq mESC enhancer starr_47559 Neighboring gene STARR-positive B cell enhancer ABC_E8763 Neighboring gene microRNA 7673 Neighboring gene predicted gene 5400 Neighboring gene predicted gene 14826

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC47138

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nuclear protein quality control by the ubiquitin-proteasome system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear protein quality control by the ubiquitin-proteasome system ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear protein quality control by the ubiquitin-proteasome system ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039059.1 → NP_001034148.1  kelch-like protein 15 isoform c

      See identical proteins and their annotated locations for NP_001034148.1

      Status: VALIDATED

      Source sequence(s)
      AK081546, AK165342, AK169500
      Consensus CDS
      CCDS41062.1
      UniProtKB/Swiss-Prot
      A2AAX3
      Related
      ENSMUSP00000109541.2, ENSMUST00000113908.8
      Conserved Domains (2) summary
      cd18244
      Location:1 → 137
      BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
      cd18454
      Location:128 → 235
      BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

    2. NM_001039060.1 → NP_001034149.1  kelch-like protein 15 isoform b

      See identical proteins and their annotated locations for NP_001034149.1

      Status: VALIDATED

      Source sequence(s)
      AK081546, AK165342, AK169500
      Consensus CDS
      CCDS30279.1
      UniProtKB/Swiss-Prot
      A2AAX3
      Related
      ENSMUSP00000094097.4, ENSMUST00000096369.10
      Conserved Domains (3) summary
      smart00225
      Location:32 → 128
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:133 → 235
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:21 → 125
      BTB; BTB/POZ domain

    3. NM_001039061.1 → NP_001034150.1  kelch-like protein 15 isoform a

      See identical proteins and their annotated locations for NP_001034150.1

      Status: VALIDATED

      Source sequence(s)
      AK078112, AK081546, AK133055, AL646049
      Consensus CDS
      CCDS30278.1
      UniProtKB/Swiss-Prot
      A2AAX3, Q3TEP6, Q8K1Y4
      Related
      ENSMUSP00000109549.4, ENSMUST00000113916.10
      Conserved Domains (4) summary
      PHA03098
      Location:33 → 576
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:417 → 474
      Kelch; KELCH repeat [structural motif]
      cd18244
      Location:1 → 137
      BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
      cd18454
      Location:128 → 235
      BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

    4. NM_153165.2 → NP_694805.1  kelch-like protein 15 isoform c

      See identical proteins and their annotated locations for NP_694805.1

      Status: VALIDATED

      Source sequence(s)
      AK081546, AK165342, AK169500
      Consensus CDS
      CCDS41062.1
      UniProtKB/Swiss-Prot
      A2AAX3
      Related
      ENSMUSP00000109544.3, ENSMUST00000113911.9
      Conserved Domains (2) summary
      cd18244
      Location:1 → 137
      BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
      cd18454
      Location:128 → 235
      BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      93275884..93321330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527986.4 → XP_006528049.1  kelch-like protein 15 isoform X1

      See identical proteins and their annotated locations for XP_006528049.1

      UniProtKB/Swiss-Prot
      A2AAX3, Q3TEP6, Q8K1Y4
      Conserved Domains (4) summary
      PHA03098
      Location:33 → 576
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:417 → 474
      Kelch; KELCH repeat [structural motif]
      cd18244
      Location:1 → 137
      BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
      cd18454
      Location:128 → 235
      BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

    2. XM_006527989.4 → XP_006528052.1  kelch-like protein 15 isoform X1

      See identical proteins and their annotated locations for XP_006528052.1

      UniProtKB/Swiss-Prot
      A2AAX3, Q3TEP6, Q8K1Y4
      Conserved Domains (4) summary
      PHA03098
      Location:33 → 576
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:417 → 474
      Kelch; KELCH repeat [structural motif]
      cd18244
      Location:1 → 137
      BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
      cd18454
      Location:128 → 235
      BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

    3. XM_006527991.5 → XP_006528054.1  kelch-like protein 15 isoform X2

      See identical proteins and their annotated locations for XP_006528054.1

      UniProtKB/Swiss-Prot
      A2AAX3
      Conserved Domains (2) summary
      cd18244
      Location:1 → 137
      BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
      cd18454
      Location:128 → 235
      BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

    4. XM_030251323.2 → XP_030107183.1  kelch-like protein 15 isoform X2

      Conserved Domains (2) summary
      cd18244
      Location:1 → 137
      BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
      cd18454
      Location:128 → 235
      BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

    5. XM_030251322.2 → XP_030107182.1  kelch-like protein 15 isoform X1

      UniProtKB/Swiss-Prot
      A2AAX3, Q3TEP6, Q8K1Y4
      Related
      ENSMUSP00000129734.2, ENSMUST00000170594.8
      Conserved Domains (4) summary
      PHA03098
      Location:33 → 576
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:417 → 474
      Kelch; KELCH repeat [structural motif]
      cd18244
      Location:1 → 137
      BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
      cd18454
      Location:128 → 235
      BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

    6. XM_006527990.5 → XP_006528053.1  kelch-like protein 15 isoform X1

      See identical proteins and their annotated locations for XP_006528053.1

      UniProtKB/Swiss-Prot
      A2AAX3, Q3TEP6, Q8K1Y4
      Conserved Domains (4) summary
      PHA03098
      Location:33 → 576
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:417 → 474
      Kelch; KELCH repeat [structural motif]
      cd18244
      Location:1 → 137
      BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
      cd18454
      Location:128 → 235
      BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

    7. XM_006527987.4 → XP_006528050.1  kelch-like protein 15 isoform X1

      See identical proteins and their annotated locations for XP_006528050.1

      UniProtKB/Swiss-Prot
      A2AAX3, Q3TEP6, Q8K1Y4
      Conserved Domains (4) summary
      PHA03098
      Location:33 → 576
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:417 → 474
      Kelch; KELCH repeat [structural motif]
      cd18244
      Location:1 → 137
      BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
      cd18454
      Location:128 → 235
      BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

    8. XM_011247581.1 → XP_011245883.1  kelch-like protein 15 isoform X1

      See identical proteins and their annotated locations for XP_011245883.1

      UniProtKB/Swiss-Prot
      A2AAX3, Q3TEP6, Q8K1Y4
      Related
      ENSMUSP00000109548.2, ENSMUST00000113915.2
      Conserved Domains (4) summary
      PHA03098
      Location:33 → 576
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:417 → 474
      Kelch; KELCH repeat [structural motif]
      cd18244
      Location:1 → 137
      BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
      cd18454
      Location:128 → 235
      BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

    9. XM_036161925.1 → XP_036017818.1  kelch-like protein 15 isoform X1

      UniProtKB/Swiss-Prot
      A2AAX3, Q3TEP6, Q8K1Y4
      Conserved Domains (4) summary
      PHA03098
      Location:33 → 576
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:417 → 474
      Kelch; KELCH repeat [structural motif]
      cd18244
      Location:1 → 137
      BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
      cd18454
      Location:128 → 235
      BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AAX3.1 GenPept UniProtKB/Swiss-Prot:A2AAX3

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