Tsc22d3 TSC22 domain family, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tsc22d3provided by MGI
Official Full Name: TSC22 domain family, member 3provided by MGI
Primary source: MGI:MGI:1196284
See related: Ensembl:ENSMUSG00000031431 AllianceGenome:MGI:1196284
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DIP; Gilz; Dsip1; Tilz3; TSC-22R
Summary: Acts upstream of or within negative regulation of activation-induced cell death of T cells and response to osmotic stress. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; nervous system; sensory organ; and viscerocranium. Orthologous to human TSC22D3 (TSC22 domain family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 50.5), lung adult (RPKM 48.1) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F1; X 61.35 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (139440277..139501257, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (140539528..140600522, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GILZ Modulates the Recruitment of Monocytes/Macrophages Endowed with a Resolving Phenotype and Favors Resolution of Escherichia coli Infection.
Title: GILZ Modulates the Recruitment of Monocytes/Macrophages Endowed with a Resolving Phenotype and Favors Resolution of Escherichia coli Infection.
Multi-Tissue Characterization of GILZ Expression in Dendritic Cell Subsets at Steady State and in Inflammatory Contexts.
Title: Multi-Tissue Characterization of GILZ Expression in Dendritic Cell Subsets at Steady State and in Inflammatory Contexts.
Glucocorticoid-induced leucine zipper regulates liver fibrosis by suppressing CCL2-mediated leukocyte recruitment.
Title: Glucocorticoid-induced leucine zipper regulates liver fibrosis by suppressing CCL2-mediated leukocyte recruitment.
GILZ Regulates the Expression of Pro-Inflammatory Cytokines and Protects Against End-Organ Damage in a Model of Lupus.
Title: GILZ Regulates the Expression of Pro-Inflammatory Cytokines and Protects Against End-Organ Damage in a Model of Lupus.
Deficit of glucocorticoid-induced leucine zipper amplifies angiotensin-induced cardiomyocyte hypertrophy and diastolic dysfunction.
Title: Deficit of glucocorticoid-induced leucine zipper amplifies angiotensin-induced cardiomyocyte hypertrophy and diastolic dysfunction.
Short-Chain Alcohols Upregulate GILZ Gene Expression and Attenuate LPS-Induced Septic Immune Response.
Title: Short-Chain Alcohols Upregulate GILZ Gene Expression and Attenuate LPS-Induced Septic Immune Response.
Overexpression of GILZ in macrophages limits systemic inflammation while increasing bacterial clearance in sepsis in mice.
Title: Overexpression of GILZ in macrophages limits systemic inflammation while increasing bacterial clearance in sepsis in mice.
Dramatic alterations in GILZ occur in those exposed to a stressor prenatally, in adulthood or both.
Title: Glucocorticoid-induced leucine zipper "quantifies" stressors and increases male susceptibility to PTSD.
Authors show that the testicular soma of mice with a conditional knockout (conKO) in the X-linked gene Tsc22d3 supports spermatogenesis and germline transmission from cultured mouse SSCs upon transplantation. Infertile males were produced by crossing homozygous Tsc22d3 floxed females with homozygous ROSA26-Cre males.
Title: The testicular soma of Tsc22d3 knockout mice supports spermatogenesis and germline transmission from spermatogonial stem cell lines upon transplantation.
these results indicate that stress-induced glucocorticoid surge and Tsc22d3 upregulation can subvert therapy-induced anticancer immunosurveillance.
Title: Stress-glucocorticoid-TSC22D3 axis compromises therapy-induced antitumor immunity.

Submit: New GeneRIF Correction See all GeneRIFs (64)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of activation-induced cell death of T cells	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of activation-induced cell death of T cells	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to osmotic stress	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: TSC22 domain family protein 3

Names: TSC22-related inducible leucine zipper 3; delta sleep inducing peptide, immunoreactor; glucocorticoid-induced leucine zipper protein; long glucocorticoid-induced leucine zipper protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077364.2 → NP_001070832.1 TSC22 domain family protein 3 isoform 1

See identical proteins and their annotated locations for NP_001070832.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AL683809

Consensus CDS

CCDS41150.1

UniProtKB/Swiss-Prot

Q9Z2S7

Related

ENSMUSP00000108620.3, ENSMUST00000112996.9

Conserved Domains (1) summary

pfam01166
Location:122 → 178

TSC22; TSC-22/dip/bun family
NM_010286.6 → NP_034416.3 TSC22 domain family protein 3 isoform 2

See identical proteins and their annotated locations for NP_034416.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) has a different 5' structure, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AL683809

Consensus CDS

CCDS30440.1

UniProtKB/Swiss-Prot

B1AVF3, C6EX03, Q3UNI6, Q8K160, Q9EQN0, Q9EQN1, Q9EQN2, Q9Z2S7

Conserved Domains (1) summary

cd21940
Location:57 → 137

ZIP_TSC22D3; leucine zipper domain found in TSC22 domain family protein 3

RNA

NR_122039.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) has a different 5' structure compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AL683809

Related

ENSMUST00000112995.3