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    ZNF691 zinc finger protein 691 [ Homo sapiens (human) ]

    Gene ID: 51058, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF691provided by HGNC
    Official Full Name
    zinc finger protein 691provided by HGNC
    Primary source
    HGNC:HGNC:28028
    See related
    Ensembl:ENSG00000164011 AllianceGenome:HGNC:28028
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Zfp691
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 2.2), ovary (RPKM 1.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF691 in Genome Data Viewer
    Location:
    1p34.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (42846613..42852477)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (42717094..42722959)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (43312284..43318148)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene erythroblast membrane associated protein (Scianna blood group) Neighboring gene uncharacterized LOC124904163 Neighboring gene ZNF691 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 898 Neighboring gene uncharacterized LOC339539 Neighboring gene transmembrane channel like 6 pseudogene Neighboring gene makorin ring finger protein 8, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Systematic identification of molecular links between core and candidate genes in breast cancer. Arroyo R, et al. J Mol Biol, 2015 Mar 27. PMID 25640309
    2. Large-scale concatenation cDNA sequencing. Yu W, et al. Genome Res, 1997 Apr. PMID 9110174, Free PMC Article
    3. A "double adaptor" method for improved shotgun library construction. Andersson B, et al. Anal Biochem, 1996 Apr 5. PMID 8619474
    4. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
    5. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Gordon DE, et al. Science, 2020 Dec 4. PMID 33060197, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 691

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242739.2 → NP_001229668.1  zinc finger protein 691 isoform 1

      See identical proteins and their annotated locations for NP_001229668.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AF131739, BM741761, DC378862
      Consensus CDS
      CCDS55595.1
      UniProtKB/Swiss-Prot
      A8MXP6, B4DJR7, O95878, Q5VV52, Q9NWE8
      Related
      ENSP00000498913.1, ENST00000651192.1
      Conserved Domains (3) summary
      COG5048
      Location:108 → 266
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:229 → 249
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:283 → 305
      zf-C2H2; Zinc finger, C2H2 type

    2. NM_015911.4 → NP_056995.1  zinc finger protein 691 isoform 2

      See identical proteins and their annotated locations for NP_056995.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate exons, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AF131739
      Consensus CDS
      CCDS476.1
      UniProtKB/Swiss-Prot
      Q5VV52
      Related
      ENSP00000361586.3, ENST00000372508.7
      Conserved Domains (4) summary
      COG5048
      Location:77 → 235
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:198 → 218
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:252 → 274
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:98 → 123
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      42846613..42852477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421903.1 → XP_047277859.1  zinc finger protein 691 isoform X3

      UniProtKB/TrEMBL
      Q5VV50
      Related
      ENSP00000486871.1, ENST00000630961.1

    2. XM_017001402.3 → XP_016856891.1  zinc finger protein 691 isoform X3

      UniProtKB/TrEMBL
      Q5VV50
      Conserved Domains (4) summary
      COG5048
      Location:99 → 257
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:220 → 240
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:274 → 296
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:120 → 145
      zf-H2C2_2; Zinc-finger double domain

    3. XM_047421910.1 → XP_047277866.1  zinc finger protein 691 isoform X3

      UniProtKB/TrEMBL
      Q5VV50
      Related
      ENSP00000361582.1, ENST00000372504.5

    4. XM_006710671.5 → XP_006710734.1  zinc finger protein 691 isoform X2

      Conserved Domains (4) summary
      COG5048
      Location:104 → 262
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:225 → 245
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:279 → 301
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:125 → 150
      zf-H2C2_2; Zinc-finger double domain

    5. XM_047421899.1 → XP_047277855.1  zinc finger protein 691 isoform X1

      UniProtKB/Swiss-Prot
      A8MXP6, B4DJR7, O95878, Q5VV52, Q9NWE8
      Related
      ENSP00000361581.2, ENST00000372503.2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      42717094..42722959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336866.1 → XP_054192841.1  zinc finger protein 691 isoform X3

    2. XM_054336868.1 → XP_054192843.1  zinc finger protein 691 isoform X3

    3. XM_054336865.1 → XP_054192840.1  zinc finger protein 691 isoform X2

    4. XM_054336864.1 → XP_054192839.1  zinc finger protein 691 isoform X1

    5. XM_054336867.1 → XP_054192842.1  zinc finger protein 691 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5VV52.2 GenPept UniProtKB/Swiss-Prot:Q5VV52

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