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    INTS6L integrator complex subunit 6 like [ Homo sapiens (human) ]

    Gene ID: 203522, updated on 27-Nov-2024

    Summary

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    Official Symbol
    INTS6Lprovided by HGNC
    Official Full Name
    integrator complex subunit 6 likeprovided by HGNC
    Primary source
    HGNC:HGNC:27334
    See related
    Ensembl:ENSG00000165359 AllianceGenome:HGNC:27334
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DDX26B
    Summary
    Predicted to be involved in snRNA 3'-end processing. Predicted to be part of integrator complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 6.8), bone marrow (RPKM 4.6) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See INTS6L in Genome Data Viewer
    Location:
    Xq26.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (135520660..135582510)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (133846416..133908261)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (134654585..134716435)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene CROCC pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:134583585-134584086 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:134595644-134596166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21021 Neighboring gene WDR4 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29983 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21022 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21023 Neighboring gene INTS6L antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29984 Neighboring gene ETS2 pseudogene 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:134744552-134745751 Neighboring gene sarcoma antigen 4, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Streamlined analysis schema for high-throughput identification of endogenous protein complexes. Malovannaya A, et al. Proc Natl Acad Sci U S A, 2010 Feb 9. PMID 20133760, Free PMC Article
    2. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Camargo LM, et al. Mol Psychiatry, 2007 Jan. PMID 17043677
    3. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
    4. A human MAP kinase interactome. Bandyopadhyay S, et al. Nat Methods, 2010 Oct. PMID 20936779, Free PMC Article
    5. ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication. Pearson GJ, et al. Sci Adv, 2024 Apr 5. PMID 38569033, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ41215, MGC88298, DKFZp686G0470

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    integrator complex subunit 6-like
    Names
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
    protein DDX26B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_055290.2 RefSeqGene

      Range
      5002..66852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001351601.3 → NP_001338530.1  integrator complex subunit 6-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL357834, AL391380
      Consensus CDS
      CCDS87784.1
      UniProtKB/TrEMBL
      A0A1W2PPI5, B9EIK3
      Related
      ENSP00000491427.1, ENST00000639893.2
      Conserved Domains (2) summary
      pfam13519
      Location:4 → 132
      VWA_2; von Willebrand factor type A domain
      pfam15300
      Location:814 → 875
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    2. NM_001351603.3 → NP_001338532.1  integrator complex subunit 6-like isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL357834, AL391380
      UniProtKB/TrEMBL
      B9EIK3
      Conserved Domains (2) summary
      pfam13519
      Location:4 → 132
      VWA_2; von Willebrand factor type A domain
      pfam15300
      Location:777 → 838
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    3. NM_001351604.3 → NP_001338533.1  integrator complex subunit 6-like isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL357834, AL391380
      UniProtKB/TrEMBL
      B9EIK3
      Conserved Domains (2) summary
      pfam13519
      Location:4 → 132
      VWA_2; von Willebrand factor type A domain
      pfam15300
      Location:733 → 794
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    4. NM_001351605.3 → NP_001338534.1  integrator complex subunit 6-like isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL357834, AL391380
      UniProtKB/TrEMBL
      B9EIK3
      Conserved Domains (2) summary
      pfam13519
      Location:4 → 132
      VWA_2; von Willebrand factor type A domain
      pfam15300
      Location:733 → 794
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    5. NM_001351606.3 → NP_001338535.1  integrator complex subunit 6-like isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL357834, AL391380
      Conserved Domains (1) summary
      pfam15300
      Location:535 → 596
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    6. NM_182540.7 → NP_872346.3  integrator complex subunit 6-like isoform 1

      See identical proteins and their annotated locations for NP_872346.3

      Status: VALIDATED

      Source sequence(s)
      AL357834, AL391380
      Consensus CDS
      CCDS35401.1
      UniProtKB/Swiss-Prot
      Q5CZA2, Q5JSJ4, Q6IPS3, Q6ZTU5, Q6ZWE4
      UniProtKB/TrEMBL
      B9EIK3
      Related
      ENSP00000359788.4, ENST00000370752.4
      Conserved Domains (2) summary
      cd00198
      Location:4 → 131
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam15300
      Location:777 → 838
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    RNA

    1. NR_147256.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL357834, AL391380
      Related
      ENST00000481908.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      135520660..135582510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006724740.3 → XP_006724803.1  integrator complex subunit 6-like isoform X1

      UniProtKB/TrEMBL
      B9EIK3
      Conserved Domains (2) summary
      cd00198
      Location:4 → 131
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam15300
      Location:814 → 875
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    2. XM_006724741.5 → XP_006724804.1  integrator complex subunit 6-like isoform X2

      UniProtKB/TrEMBL
      B9EIK3
      Conserved Domains (2) summary
      cd00198
      Location:4 → 131
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam15300
      Location:770 → 831
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    3. XM_024452350.2 → XP_024308118.1  integrator complex subunit 6-like isoform X3

      UniProtKB/TrEMBL
      B9EIK3
      Conserved Domains (2) summary
      pfam13519
      Location:4 → 132
      VWA_2; von Willebrand factor type A domain
      pfam15300
      Location:770 → 831
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    4. XM_047441910.1 → XP_047297866.1  integrator complex subunit 6-like isoform X10

    5. XM_017029346.2 → XP_016884835.1  integrator complex subunit 6-like isoform X12

    6. XM_011531311.3 → XP_011529613.1  integrator complex subunit 6-like isoform X13

      Conserved Domains (1) summary
      cd00198
      Location:4 → 131
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    7. XM_047441913.1 → XP_047297869.1  integrator complex subunit 6-like isoform X15

      UniProtKB/TrEMBL
      Q8N8M2

    8. XM_047441912.1 → XP_047297868.1  integrator complex subunit 6-like isoform X14

    9. XM_017029349.2 → XP_016884838.1  integrator complex subunit 6-like isoform X16

      Conserved Domains (1) summary
      cd00198
      Location:4 → 100
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    10. XM_047441909.1 → XP_047297865.1  integrator complex subunit 6-like isoform X9

    11. XM_047441907.1 → XP_047297863.1  integrator complex subunit 6-like isoform X7

    12. XM_047441905.1 → XP_047297861.1  integrator complex subunit 6-like isoform X5

    13. XM_047441908.1 → XP_047297864.1  integrator complex subunit 6-like isoform X8

    14. XM_047441904.1 → XP_047297860.1  integrator complex subunit 6-like isoform X4

    15. XM_047441906.1 → XP_047297862.1  integrator complex subunit 6-like isoform X6

    16. XM_047441911.1 → XP_047297867.1  integrator complex subunit 6-like isoform X11

    RNA

    1. XR_007068183.1 RNA Sequence

    2. XR_001755668.2 RNA Sequence

    3. XR_001755666.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      133846416..133908261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326661.1 → XP_054182636.1  integrator complex subunit 6-like isoform X1

    2. XM_054326662.1 → XP_054182637.1  integrator complex subunit 6-like isoform X2

    3. XM_054326663.1 → XP_054182638.1  integrator complex subunit 6-like isoform X3

    4. XM_054326670.1 → XP_054182645.1  integrator complex subunit 6-like isoform X10

    5. XM_054326672.1 → XP_054182647.1  integrator complex subunit 6-like isoform X12

    6. XM_054326673.1 → XP_054182648.1  integrator complex subunit 6-like isoform X13

    7. XM_054326675.1 → XP_054182650.1  integrator complex subunit 6-like isoform X15

      UniProtKB/TrEMBL
      Q8N8M2

    8. XM_054326674.1 → XP_054182649.1  integrator complex subunit 6-like isoform X14

    9. XM_054326676.1 → XP_054182651.1  integrator complex subunit 6-like isoform X16

    10. XM_054326668.1 → XP_054182643.1  integrator complex subunit 6-like isoform X9

    11. XM_054326667.1 → XP_054182642.1  integrator complex subunit 6-like isoform X7

    12. XM_054326665.1 → XP_054182640.1  integrator complex subunit 6-like isoform X5

    13. XM_054326669.1 → XP_054182644.1  integrator complex subunit 6-like isoform X8

    14. XM_054326664.1 → XP_054182639.1  integrator complex subunit 6-like isoform X4

    15. XM_054326666.1 → XP_054182641.1  integrator complex subunit 6-like isoform X6

    16. XM_054326671.1 → XP_054182646.1  integrator complex subunit 6-like isoform X11

    RNA

    1. XR_008485465.1 RNA Sequence

    2. XR_008485467.1 RNA Sequence

    3. XR_008485466.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5JSJ4.1 GenPept UniProtKB/Swiss-Prot:Q5JSJ4

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