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    uncharacterized protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852540, updated on 9-Dec-2024

    Summary

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    Official Full Name
    uncharacterized protein
    Primary source
    SGD:S000000442
    Locus tag
    YBR238C
    See related
    AllianceGenome:SGD:S000000442; FungiDB:YBR238C; VEuPathDB:YBR238C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity. Involved in aerobic respiration. Located in P-body and mitochondrial membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (695107..697302, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene mRNA (guanine-N7)-methyltransferase Neighboring gene DEAD-box RNA helicase PRP5 Neighboring gene Ert1p Neighboring gene Thi2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Uncharacterized yeast gene YBR238C, an effector of TORC1 signaling in a mitochondrial feedback loop, accelerates cellular aging via HAP4- and RMD9-dependent mechanisms. Alfatah M, et al. Elife, 2024 May 7. PMID 38713053, Free PMC Article
    2. Rmd9p controls the processing/stability of mitochondrial mRNAs and its overexpression compensates for a partial deficiency of oxa1p in Saccharomyces cerevisiae. Nouet C, et al. Genetics, 2007 Mar. PMID 17194787, Free PMC Article
    3. Misfolding of mutant adenine nucleotide translocase in yeast supports a novel mechanism of Ant1-induced muscle diseases. Liu Y, et al. Mol Biol Cell, 2015 Jun 1. PMID 25833713, Free PMC Article
    4. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Kaeberlein M, et al. Science, 2005 Nov 18. PMID 16293764
    5. Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Delaney JR, et al. Aging Cell, 2011 Dec. PMID 21902802, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Uncharacterized yeast gene YBR238C, an effector of TORC1 signaling in a mitochondrial feedback loop, accelerates cellular aging via HAP4- and RMD9-dependent mechanisms.
      Title: Uncharacterized yeast gene YBR238C, an effector of TORC1 signaling in a mitochondrial feedback loop, accelerates cellular aging via HAP4- and RMD9-dependent mechanisms.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in aerobic respiration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_009797.1
    • Mitochondrial membrane protein; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span; YBR238C has a paralog, RMD9, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      695107..697302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178586.1 → NP_009797.1  TPA: uncharacterized protein YBR238C [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009797.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQN4, P38330
      UniProtKB/TrEMBL
      A6ZLH7, B3LMS4, C7GMR5, D3UEY6, G2W9P1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38330.1

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