Tnnt3 troponin T3, fast skeletal type [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tnnt3provided by RGD
Official Full Name: troponin T3, fast skeletal typeprovided by RGD
Primary source: RGD:3883
See related: EnsemblRapid:ENSRNOG00000020332 AllianceGenome:RGD:3883
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tnt
Summary: Predicted to enable calcium-dependent protein binding activity and cytoskeletal protein binding activity. Predicted to contribute to actin binding activity. Involved in regulation of striated muscle contraction. Part of troponin complex. Human ortholog(s) of this gene implicated in distal arthrogryposis type 2B and distal arthrogryposis type 2B2. Orthologous to human TNNT3 (troponin T3, fast skeletal type). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 56590.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (207082014..207099014)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (197652535..197669736)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (215666628..215683628)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Weight-dependent quantitative variation in Tnnt3 alternative splicing appears to be an evolutionarily conserved feature of skeletal muscle.
Title: Body weight-dependent troponin T alternative splicing is evolutionarily conserved from insects to mammals and is partially impaired in skeletal muscle of obese rats.
HU induced profound slow-to-fast isoform transitions of all Tn subunits, although to different extents and with different time courses. This suggests that slow and fast counterparts of Tn subunit isoforms are regulated independently in response to HU.
Title: Time-dependent changes in expression of troponin subunit isoforms in unloaded rat soleus muscle.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

d1arb23 (e-PCR)
- UniSTS:121443

Tnnt3 (e-PCR), detects polymorphism
- UniSTS:547474

D1Wox55 (e-PCR)
- UniSTS:239561

RH139831 (e-PCR)
- UniSTS:221915

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
contributes_to actin binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables tropomyosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tropomyosin binding	IEA Inferred from Electronic Annotation more info
contributes_to tropomyosin binding	ISO Inferred from Sequence Orthology more info
enables tropomyosin binding	ISO Inferred from Sequence Orthology more info
enables troponin C binding	IBA Inferred from Biological aspect of Ancestor more info
enables troponin C binding	IEA Inferred from Electronic Annotation more info
enables troponin C binding	ISO Inferred from Sequence Orthology more info
enables troponin I binding	IBA Inferred from Biological aspect of Ancestor more info
enables troponin I binding	IEA Inferred from Electronic Annotation more info
enables troponin I binding	ISO Inferred from Sequence Orthology more info
enables troponin T binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in muscle contraction	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of calcium-dependent ATPase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of ATP-dependent activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of striated muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of striated muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of striated muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of troponin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of troponin complex	IDA Inferred from Direct Assay more info	PubMed
part_of troponin complex	IEA Inferred from Electronic Annotation more info
part_of troponin complex	ISO Inferred from Sequence Orthology more info
part_of troponin complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: troponin T, fast skeletal muscle

Names: fTnT; fast skeletal muscle troponin T; tnTf; troponin T type 3 (skeletal, fast); troponin T3, skeletal, fast

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270664.1 → NP_001257593.1 troponin T, fast skeletal muscle isoform 11

See identical proteins and their annotated locations for NP_001257593.1

Status: VALIDATED

Description

Transcript Variant: This variant (11) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (11) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

CB612473, JAXUCZ010000001

UniProtKB/TrEMBL

A6HY62

Conserved Domains (1) summary

pfam00992
Location:52 → 188

Troponin
NM_001270665.1 → NP_001257594.1 troponin T, fast skeletal muscle isoform 1

See identical proteins and their annotated locations for NP_001257594.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) and variant 2 represent the longest transcripts and encode the longest isoforms (1 and 2).

Source sequence(s)

CB612473, JAXUCZ010000001

UniProtKB/Swiss-Prot

P09739, P09740, Q304F4, Q4PPA0

UniProtKB/TrEMBL

A6HY59, A6HY62

Conserved Domains (1) summary

pfam00992
Location:63 → 199

Troponin
NM_001270666.1 → NP_001257595.1 troponin T, fast skeletal muscle isoform 2

See identical proteins and their annotated locations for NP_001257595.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) and variant 1 represent the longest transcripts and encode the longest isoforms (2 and 1).

Source sequence(s)

CB612473, JAXUCZ010000001

UniProtKB/TrEMBL

A6HY61

Related

ENSRNOP00000062891.5, ENSRNOT00000063918.6

Conserved Domains (1) summary

pfam00992
Location:63 → 199

Troponin
NM_001270668.1 → NP_001257597.1 troponin T, fast skeletal muscle isoform 3

See identical proteins and their annotated locations for NP_001257597.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two alternate in-frame exons and uses an alternate exon in place of another exon in the 3' end of the gene, compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter and has a different internal segment compared to isoform 1.

Source sequence(s)

CB612473, JAXUCZ010000001

UniProtKB/TrEMBL

A6HY61

Conserved Domains (1) summary

pfam00992
Location:52 → 188

Troponin
NM_001270670.1 → NP_001257599.1 troponin T, fast skeletal muscle isoform 4

See identical proteins and their annotated locations for NP_001257599.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate exon in place of another exon in the 3' end of the gene, compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter and has a different internal segment compared to isoform 1.

Source sequence(s)

CB612473, JAXUCZ010000001

UniProtKB/TrEMBL

A6HY61

Conserved Domains (1) summary

pfam00992
Location:57 → 193

Troponin
NM_001270671.1 → NP_001257600.1 troponin T, fast skeletal muscle isoform 5

See identical proteins and their annotated locations for NP_001257600.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

CB612473, JAXUCZ010000001

UniProtKB/TrEMBL

A6HY62

Related

ENSRNOP00000062653.4, ENSRNOT00000066135.5

Conserved Domains (1) summary

pfam00992
Location:57 → 193

Troponin
NM_001270672.1 → NP_001257601.1 troponin T, fast skeletal muscle isoform 6

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

CB612473, JAXUCZ010000001

UniProtKB/TrEMBL

A6HY62

Conserved Domains (1) summary

pfam00992
Location:54 → 190

Troponin
NM_001270673.1 → NP_001257602.1 troponin T, fast skeletal muscle isoform 7

See identical proteins and their annotated locations for NP_001257602.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (7) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

CB612473, JAXUCZ010000001

UniProtKB/TrEMBL

A6HY62

Related

ENSRNOP00000059829.2, ENSRNOT00000066896.6

Conserved Domains (1) summary

pfam00992
Location:58 → 194

Troponin
NM_001270675.1 → NP_001257604.1 troponin T, fast skeletal muscle isoform 9

Status: VALIDATED

Description

Transcript Variant: This variant (9) lacks two alternate in-frame exons and uses an alternate exon in place of another exon in the 3' end of the gene, compared to variant 1. The resulting isoform (9) has the same N- and C-termini but is shorter and has a different internal segment compared to isoform 1.

Source sequence(s)

CB612473, JAXUCZ010000001

UniProtKB/TrEMBL

A6HY61

Conserved Domains (1) summary

pfam00992
Location:54 → 190

Troponin
NM_001270676.1 → NP_001257605.1 troponin T, fast skeletal muscle isoform 10

See identical proteins and their annotated locations for NP_001257605.1

Status: VALIDATED

Description

Transcript Variant: This variant (10) lacks an alternate in-frame exon and uses an alternate exon in place of another exon in the 3' end of the gene, compared to variant 1. The resulting isoform (10) has the same N- and C-termini but is shorter and has a different internal segment compared to isoform 1.

Source sequence(s)

CB612473, JAXUCZ010000001

UniProtKB/TrEMBL

A6HY61

Conserved Domains (1) summary

pfam00992
Location:58 → 194

Troponin
NM_001270677.1 → NP_001257606.1 troponin T, fast skeletal muscle isoform 12

Status: VALIDATED

Description

Transcript Variant: This variant (12) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (12) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

CB612473, JAXUCZ010000001

UniProtKB/TrEMBL

A6HY62

Conserved Domains (1) summary

pfam00992
Location:48 → 183

Troponin; Troponin
NM_001270678.1 → NP_001257607.1 troponin T, fast skeletal muscle isoform 13

See identical proteins and their annotated locations for NP_001257607.1

Status: VALIDATED

Description

Transcript Variant: This variant (13) lacks an alternate in-frame exon and uses an alternate exon in place of another exon in the 3' end of the gene, compared to variant 1. The resulting isoform (13) has the same N- and C-termini but is shorter and has a different internal segment compared to isoform 1.

Source sequence(s)

CB612473, JAXUCZ010000001

UniProtKB/TrEMBL

A6HY61

Conserved Domains (1) summary

pfam00992
Location:59 → 195

Troponin
NM_031532.2 → NP_113720.1 troponin T, fast skeletal muscle isoform 8

See identical proteins and their annotated locations for NP_113720.1

Status: VALIDATED

Description

Transcript Variant: This variant (8) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (8) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

CB612473, JAXUCZ010000001

UniProtKB/TrEMBL

A6HY60, A6HY62

Conserved Domains (1) summary

pfam00992
Location:59 → 195

Troponin