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    Abcb11 ATP-binding cassette, sub-family B member 11 [ Mus musculus (house mouse) ]

    Gene ID: 27413, updated on 27-Nov-2024

    Summary

    Official Symbol
    Abcb11provided by MGI
    Official Full Name
    ATP-binding cassette, sub-family B member 11provided by MGI
    Primary source
    MGI:MGI:1351619
    See related
    Ensembl:ENSMUSG00000027048 AllianceGenome:MGI:1351619
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bsep; PGY4; SPGP; ABC16; Lith1; PFIC2
    Summary
    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt transporter in humans and mice. Mutations in the human gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in liver adult (RPKM 44.5) and liver E18 (RPKM 21.7) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Abcb11 in Genome Data Viewer
    Location:
    2 C2; 2 39.69 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (69068626..69172960, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (69238282..69342616, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene nitric oxide synthase trafficker Neighboring gene STARR-positive B cell enhancer ABC_E412 Neighboring gene STARR-seq mESC enhancer starr_04729 Neighboring gene SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) Neighboring gene glucose-6-phosphatase, catalytic, 2 Neighboring gene STARR-seq mESC enhancer starr_04731 Neighboring gene STARR-seq mESC enhancer starr_04732 Neighboring gene predicted gene, 36393 Neighboring gene dehydrogenase/reductase 9 Neighboring gene STARR-seq mESC enhancer starr_04734 Neighboring gene STARR-seq mESC enhancer starr_04735 Neighboring gene low density lipoprotein receptor-related protein 2 Neighboring gene STARR-seq mESC enhancer starr_04736

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ABC-type bile acid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ABC-type bile acid transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ABC-type bile acid transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ABC-type xenobiotic transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ABC-type xenobiotic transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables bile acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables bile acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables bile acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables canalicular bile acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables canalicular bile acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables canalicular bile acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables canalicular bile acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables carbohydrate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables carbohydrate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bile acid and bile salt transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bile acid and bile salt transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in bile acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bile acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in canalicular bile acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in canalicular bile acid transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in canalicular bile acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in canalicular bile acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in carbohydrate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phospholipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of bile acid secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of bile acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to estrogen IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic export from cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic export from cell ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in xenobiotic transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intercellular canaliculus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular canaliculus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular canaliculus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    bile salt export pump
    Names
    ATP-binding cassette, sub-family B (MDR/TAP), member 11
    sister of P-glycoprotein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363492.1NP_001350421.1  bile salt export pump

      Status: REVIEWED

      Source sequence(s)
      AL929170
      Consensus CDS
      CCDS16090.1
      UniProtKB/Swiss-Prot
      A2AUN4, Q9QY30, Q9QZE8
      Conserved Domains (1) summary
      cl28181
      Location:291314
      AAA; ATPases associated with a variety of cellular activities
    2. NM_021022.3NP_066302.2  bile salt export pump

      See identical proteins and their annotated locations for NP_066302.2

      Status: REVIEWED

      Source sequence(s)
      AF186585, AI116345, AI316041, AI662666, AK144553, AL929170
      Consensus CDS
      CCDS16090.1
      UniProtKB/Swiss-Prot
      A2AUN4, Q9QY30, Q9QZE8
      Related
      ENSMUSP00000099771.4, ENSMUST00000102710.10
      Conserved Domains (1) summary
      cl28181
      Location:291314
      AAA; ATPases associated with a variety of cellular activities

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      69068626..69172960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499670.5XP_006499733.1  bile salt export pump isoform X1

      Conserved Domains (1) summary
      PTZ00265
      Location:7912
      PTZ00265; multidrug resistance protein (mdr1); Provisional