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    CG5916 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41960, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5916provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038401
    Locus tag
    Dmel_CG5916
    See related
    AllianceGenome:FB:FBgn0038401
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5916
    Summary
    Predicted to enable GTPase activator activity. Is expressed in adult head and organism. Orthologous to human GRTP1 (growth hormone regulated TBC protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5916 in Genome Data Viewer
    Location:
    89B6-89B6; 3-58 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16147029..16149636)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11972751..11975358)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Akt kinase Neighboring gene Stubble Neighboring gene MICOS subunit 26/27 Neighboring gene 48 related 2 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43472 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins. Gabernet-Castello C, et al. Mol Biol Cell, 2013 May. PMID 23485563, Free PMC Article
    2. Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency. Cheli VT, et al. Hum Mol Genet, 2010 Mar 1. PMID 20015953, Free PMC Article
    3. Evi5 promotes collective cell migration through its Rab-GAP activity. Laflamme C, et al. J Cell Biol, 2012 Jul 9. PMID 22778279, Free PMC Article
    4. GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Bernards A. Biochim Biophys Acta, 2003 Mar 17. PMID 12618308
    5. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5916-PA
    CG5916-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16147029..16149636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300428.1 → NP_001287357.1  uncharacterized protein Dmel_CG5916, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287357.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZZ9, Q9VEY4
      Conserved Domains (1) summary
      smart00164
      Location:67 → 276
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    2. NM_142267.3 → NP_650524.1  uncharacterized protein Dmel_CG5916, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650524.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZZ9, Q9VEY4
      Related
      FBpp0082705
      Conserved Domains (1) summary
      smart00164
      Location:67 → 276
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VEY4 Q9VEY4

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