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    fray frayed [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44233, updated on 17-Dec-2024

    Summary

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    Official Symbol
    frayprovided by FlyBase
    Official Full Name
    frayedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023083
    Locus tag
    Dmel_CG7693
    See related
    AllianceGenome:FB:FBgn0023083
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4624; CG7693; Dmel\CG7693; dOSR1; Dosr1; dSTRAD; Fray; l(3)07551; lag; STE20-like/SPAK
    Summary
    Enables protein serine/threonine kinase activity. Involved in axon ensheathment; protein localization to cell cortex; and wing disc development. Located in cytoplasm. Is expressed in several structures, including exit glial cell; gut section; larval thoracic perisympathetic organ; and muscle cell of ventral oblique muscle 6. Orthologous to several human genes including STK39 (serine/threonine kinase 39). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fray in Genome Data Viewer
    Location:
    91B4-91B5; 3-64 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18573091..18589459)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14398813..14415181)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene hemotin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene qin Neighboring gene Testis-specific serine/threonine kinase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fray, a Drosophila serine/threonine kinase homologous to mammalian PASK, is required for axonal ensheathment. Leiserson WM, et al. Neuron, 2000 Dec. PMID 11163267
    2. A glial investment of axons defrayed. Einheber S, et al. Neuron, 2000 Dec. PMID 11163251
    3. Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the Drosophila renal tubule. Wu Y, et al. J Biol Chem, 2014 Sep 19. PMID 25086033, Free PMC Article
    4. Massive excretion of calcium oxalate from late prepupal salivary glands of Drosophila melanogaster demonstrates active nephridial-like anion transport. Farkaš R, et al. Dev Growth Differ, 2016 Aug. PMID 27397870
    5. Intracellular chloride: a regulator of transepithelial transport in the distal nephron. Rodan AR. Curr Opin Nephrol Hypertens, 2019 Jul. PMID 30865168, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The glial sodium-potassium-2-chloride cotransporter is required for synaptic transmission in the Drosophila visual system.
      Title: The glial sodium-potassium-2-chloride cotransporter is required for synaptic transmission in the Drosophila visual system.
    2. The Drosophila WNK-SPAK/OSR1-NKCC cascade is an essential molecular pathway for osmoregulation.
      Title: Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the Drosophila renal tubule.
    3. This study proposed that normally functioning nerves generate extracellular solutes that are removed by Ncc69 under the control of Fray.
      Title: Drosophila glia use a conserved cotransporter mechanism to regulate extracellular volume.
    4. We suggest from those results that Mo25 and Fray operate together or in the same pathway in Drosophila asymmetric processes, and that their function counterbalances Lkb1.
      Title: The GC kinase Fray and Mo25 regulate Drosophila asymmetric divisions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon ensheathment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular hyperosmotic response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to cell cortex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    frayed
    Names
    CG7693-PA
    CG7693-PB
    CG7693-PC
    CG7693-PE
    CG7693-PF
    CG7693-PG
    CG7693-PI
    CG7693-PJ
    Osr1 serine/threonine-protein kinase
    Ste20-like
    Ste20-like protein kinase
    fray-PA
    fray-PB
    fray-PC
    fray-PE
    fray-PF
    fray-PG
    fray-PI
    fray-PJ
    laggard
    oxidative-stress-responsive kinase 1
    NP_001138077.1
    NP_001138078.1
    NP_001138079.1
    NP_001287395.1
    NP_001303449.2
    NP_001303450.1
    NP_477308.1
    NP_732352.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18573091..18589459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300466.1 → NP_001287395.1  frayed, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287395.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96307, Q7KSD3, Q9VE62
      Conserved Domains (2) summary
      smart00220
      Location:38 → 312
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06610
      Location:36 → 312
      STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

    2. NM_057960.4 → NP_477308.1  frayed, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477308.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96307, Q7KSD3, Q9VE62
      Related
      FBpp0083057
      Conserved Domains (2) summary
      smart00220
      Location:38 → 312
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06610
      Location:36 → 312
      STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

    3. NM_001144605.2 → NP_001138077.1  frayed, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138077.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96307, Q7KSD3, Q9VE62
      Conserved Domains (2) summary
      smart00220
      Location:38 → 312
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06610
      Location:36 → 312
      STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

    4. NM_001316520.1 → NP_001303449.2  frayed, isoform J [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A126GUV7
      Conserved Domains (2) summary
      cd06610
      Location:191 → 467
      STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
      pfam12202
      Location:613 → 670
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    5. NM_001316521.1 → NP_001303450.1  frayed, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96307, Q7KSD3, Q9VE62
      Conserved Domains (2) summary
      smart00220
      Location:38 → 312
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06610
      Location:36 → 312
      STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

    6. NM_169823.2 → NP_732352.1  frayed, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732352.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96307, Q7KSD3, Q9VE62
      Related
      FBpp0083058
      Conserved Domains (2) summary
      smart00220
      Location:38 → 312
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06610
      Location:36 → 312
      STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

    7. NM_001144607.2 → NP_001138079.1  frayed, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138079.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96307, Q7KSD3, Q9VE62
      Conserved Domains (2) summary
      smart00220
      Location:38 → 312
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06610
      Location:36 → 312
      STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

    8. NM_001144606.1 → NP_001138078.1  frayed, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138078.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96307, Q7KSD3, Q9VE62
      Conserved Domains (2) summary
      smart00220
      Location:38 → 312
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06610
      Location:36 → 312
      STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A126GUV7 A0A126GUV7
    Q7KSD3 Q7KSD3
    Q9VE62 Q9VE62

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