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    HUWE1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32510, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HUWE1provided by FlyBase
    Official Full Name
    HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0030674
    Locus tag
    Dmel_CG8184
    See related
    AllianceGenome:FB:FBgn0030674
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8184; dHUWE1; Dmel\CG8184; huwe1; Huwe1; URE-B1/CG8184
    Summary
    Predicted to enable ubiquitin protein ligase activity. Involved in several processes, including dsRNA transport; negative regulation of signal transduction; and regulation of axonogenesis. Located in nucleus. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Turner type. Orthologous to human HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See HUWE1 in Genome Data Viewer
    Location:
    13E8-13E12; 1-51 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15712628..15731935)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15606661..15625968)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Huntingtin-associated protein 40 kDa Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Magnetic receptor Neighboring gene Actin-related protein 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FMRP-dependent production of large dosage-sensitive proteins is highly conserved. Flanagan K, et al. Genetics, 2022 Jul 30. PMID 35731217, Free PMC Article
    2. The WWE domain: a common interaction module in protein ubiquitination and ADP ribosylation. Aravind L. Trends Biochem Sci, 2001 May. PMID 11343911
    3. Fragile X mental retardation 1 gene enhances the translation of large autism-related proteins. Greenblatt EJ, et al. Science, 2018 Aug 17. PMID 30115809, Free PMC Article
    4. Ubiquitin ligase HUWE1 regulates axon branching through the Wnt/β-catenin pathway in a Drosophila model for intellectual disability. Vandewalle J, et al. PLoS One, 2013. PMID 24303071, Free PMC Article
    5. FKBP39 controls nutrient dependent Nprl3 expression and TORC1 activity in Drosophila. Zhou Y, et al. Cell Death Dis, 2021 Jun 2. PMID 34078879, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of negative regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in salivary gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
    Names
    CG8184-PB
    CG8184-PC
    CG8184-PD
    CG8184-PE
    CG8184-PF
    CG8184-PG
    CG8184-PH
    HUWE1-PB
    HUWE1-PC
    HUWE1-PD
    HUWE1-PE
    HUWE1-PF
    HUWE1-PG
    HUWE1-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15712628..15731935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298361.1 → NP_001285290.1  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285290.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JC16
      Conserved Domains (8) summary
      smart00678
      Location:1761 → 1833
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      smart00119
      Location:4819 → 5147
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:4795 → 5148
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam06012
      Location:94 → 330
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:626 → 994
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3674 → 3778
      DUF4414; Domain of unknown function (DUF4414)
      pfam16122
      Location:3574 → 3650
      40S_SA_C; 40S ribosomal protein SA C-terminus
      cl21463
      Location:1472 → 1511
      UBA_like_SF; UBA domain-like superfamily

    2. NM_001298363.1 → NP_001285292.1  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285292.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JKH9
      Conserved Domains (8) summary
      smart00678
      Location:1757 → 1829
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03247
      Location:3366 → 3625
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4772 → 5125
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam06012
      Location:90 → 326
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:622 → 990
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3646 → 3675
      DUF4414; Domain of unknown function (DUF4414)
      pfam17823
      Location:3528 → 3643
      DUF5585; Family of unknown function (DUF5585)
      cl21463
      Location:1468 → 1507
      UBA_like_SF; UBA domain-like superfamily

    3. NM_001298362.1 → NP_001285291.1  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285291.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JDY2
      Conserved Domains (8) summary
      smart00678
      Location:1757 → 1829
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      smart00119
      Location:4785 → 5113
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:4761 → 5114
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam06012
      Location:90 → 326
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:622 → 990
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3640 → 3744
      DUF4414; Domain of unknown function (DUF4414)
      pfam16122
      Location:3540 → 3616
      40S_SA_C; 40S ribosomal protein SA C-terminus
      cl21463
      Location:1468 → 1507
      UBA_like_SF; UBA domain-like superfamily

    4. NM_001298359.1 → NP_001285288.1  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285288.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JF73
      Conserved Domains (8) summary
      smart00678
      Location:1756 → 1828
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      smart00119
      Location:4820 → 5148
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:4796 → 5149
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam06012
      Location:90 → 326
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:621 → 989
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3675 → 3779
      DUF4414; Domain of unknown function (DUF4414)
      pfam16122
      Location:3575 → 3651
      40S_SA_C; 40S ribosomal protein SA C-terminus
      cl21463
      Location:1467 → 1506
      UBA_like_SF; UBA domain-like superfamily

    5. NM_001298364.1 → NP_001285293.1  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285293.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JF83
      Conserved Domains (8) summary
      smart00678
      Location:1757 → 1829
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      smart00119
      Location:4770 → 5098
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:4746 → 5099
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam06012
      Location:90 → 326
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:622 → 990
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3625 → 3729
      DUF4414; Domain of unknown function (DUF4414)
      pfam16122
      Location:3525 → 3601
      40S_SA_C; 40S ribosomal protein SA C-terminus
      cl21463
      Location:1468 → 1507
      UBA_like_SF; UBA domain-like superfamily

    6. NM_132831.2 → NP_573059.1  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573059.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXR3
      Related
      FBpp0073898
      Conserved Domains (8) summary
      smart00678
      Location:1757 → 1829
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      smart00119
      Location:4815 → 5143
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:4791 → 5144
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam06012
      Location:90 → 326
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:622 → 990
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3670 → 3774
      DUF4414; Domain of unknown function (DUF4414)
      pfam16122
      Location:3570 → 3646
      40S_SA_C; 40S ribosomal protein SA C-terminus
      cl21463
      Location:1468 → 1507
      UBA_like_SF; UBA domain-like superfamily

    7. NM_001298360.1 → NP_001285289.1  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285289.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JFK0
      Conserved Domains (8) summary
      smart00678
      Location:1756 → 1828
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      smart00119
      Location:4814 → 5142
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:4790 → 5143
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam06012
      Location:90 → 326
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:621 → 989
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3669 → 3773
      DUF4414; Domain of unknown function (DUF4414)
      pfam16122
      Location:3569 → 3645
      40S_SA_C; 40S ribosomal protein SA C-terminus
      cl21463
      Location:1467 → 1506
      UBA_like_SF; UBA domain-like superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T3L0 Q8T3L0
    Q9VXR3 Q9VXR3
    X2JC16 X2JC16
    X2JDY2 X2JDY2
    X2JF73 X2JF73
    X2JF83 X2JF83
    X2JFK0 X2JFK0
    X2JKH9 X2JKH9

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