Drgx dorsal root ganglia homeobox [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Drgxprovided by RGD
Official Full Name: dorsal root ganglia homeoboxprovided by RGD
Primary source: RGD:628616
See related: EnsemblRapid:ENSRNOG00000020045 AllianceGenome:RGD:628616
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Drg11; Prrxl1
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including detection of temperature stimulus; nervous system development; and sensory perception of mechanical stimulus. Predicted to be located in nucleus. Orthologous to human DRGX (dorsal root ganglia homeobox). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 3.1), Adrenal (RPKM 2.0) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p16

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (7861024..7891607)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (7854849..7884404)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (8823872..8853430)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dorsal Root Ganglia Homeobox downregulation in primary sensory neurons contributes to neuropathic pain in rats.
Title: Dorsal Root Ganglia Homeobox downregulation in primary sensory neurons contributes to neuropathic pain in rats.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in detection of chemical stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within detection of chemical stimulus	ISO Inferred from Sequence Orthology more info
involved_in detection of temperature stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within detection of temperature stimulus	ISO Inferred from Sequence Orthology more info
involved_in dorsal spinal cord development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dorsal spinal cord development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of mechanical stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in trigeminal nerve development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within trigeminal nerve development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dorsal root ganglia homeobox protein

Names: dorsal root ganglion 11; homeobox protein DRG11; paired-like homeodomain trancription factor Drg11; paired-related homeobox protein-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145767.2 → NP_665710.2 dorsal root ganglia homeobox protein

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

Q62798

UniProtKB/TrEMBL

A6KFV5, G3V8N6

Related

ENSRNOP00000027186.3, ENSRNOT00000027186.5

Conserved Domains (2) summary

pfam00046
Location:37 → 90

Homeobox; Homeobox domain

pfam03826
Location:201 → 218

OAR; OAR domain