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    fitm-2 Acyl-coenzyme A diphosphatase FITM2 [ Caenorhabditis elegans ]

    Gene ID: 3565961, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fitm-2
    Official Full Name
    Acyl-coenzyme A diphosphatase FITM2
    Primary source
    WormBase:WBGene00044094
    Locus tag
    CELE_ZK265.9
    See related
    AllianceGenome:WB:WBGene00044094
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable coenzyme A diphosphatase activity. Involved in lipid droplet formation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Siddiqi syndrome. Orthologous to several human genes including FITM2 (fat storage inducing transmembrane protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fitm-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (8253456..8254926, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Homeobox domain-containing protein;Homeobox protein ceh-8 Neighboring gene Nucleolar protein 16 Neighboring gene Serpentine Receptor, class E (Epsilon) Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Keeping FIT, storing fat: Lipid droplet biogenesis. Choudhary V, et al. Worm, 2016 Apr-Jun. PMID 27383728, Free PMC Article
    2. A conserved family of proteins facilitates nascent lipid droplet budding from the ER. Choudhary V, et al. J Cell Biol, 2015 Oct 26. PMID 26504167, Free PMC Article
    3. Evolutionarily conserved gene family important for fat storage. Kadereit B, et al. Proc Natl Acad Sci U S A, 2008 Jan 8. PMID 18160536, Free PMC Article
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables coenzyme A diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables coenzyme A diphosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty-acyl-CoA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid droplet formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid droplet formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid droplet organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid storage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid storage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Acyl-coenzyme A diphosphatase FITM2
    NP_001021865.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8253456..8254926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026694.7 → NP_001021865.1  Acyl-coenzyme A diphosphatase FITM2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021865.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5CZ37
      Conserved Domains (1) summary
      pfam10261
      Location:75 → 263
      Scs3p; Inositol phospholipid synthesis and fat-storage-inducing TM
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5CZ37.1

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