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    pdsA cAMP phosphodiesterase [ Dictyostelium discoideum AX4 ]

    Gene ID: 8625393, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pdsA
    Official Full Name
    cAMP phosphodiesterase
    Primary source
    dictyBase:DDB_G0285995
    Locus tag
    DDB_G0285995
    See related
    AmoebaDB:DDB_G0285995; VEuPathDB:DDB_G0285995
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Dictyostelium discoideum AX4 (strain: AX4)
    Lineage
    Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; Dictyosteliaceae; Dictyostelium
    Old locus tag
    DDBDRAFT_0218779; DDBDRAFT_0219974; DDB_0218779; DDB_0219974
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    2
    Sequence:
    Chromosome: 4; NC_007090.3 (3929775..3931286, complement)

    Chromosome 4 - NC_007090.3Genomic Context describing neighboring genes Neighboring gene ABC transporter-related protein Neighboring gene leucine-rich repeat-containing protein Neighboring gene RNA recognition motif-containing protein RRM Neighboring gene TMEM33 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_007090.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The group migration of Dictyostelium cells is regulated by extracellular chemoattractant degradation. Garcia GL, et al. Mol Biol Cell, 2009 Jul. PMID 19477920, Free PMC Article
    2. Purification and characterization of the extracellular cyclic AMP phosphodiesterase of Dictyostelium discoideum. Noce T, et al. J Biochem, 1983 Jan. PMID 6302095
    3. The extracellular cyclic nucleotide phosphodiesterase of Dictyostelium discoideum. Purification and characterization. Orlow SJ, et al. J Biol Chem, 1981 Jul 25. PMID 6265455
    4. Conditions that alter intracellular cAMP levels affect expression of the cAMP phosphodiesterase gene in Dictyostelium. Riley BB, et al. Proc Natl Acad Sci U S A, 1990 Jun. PMID 2162056, Free PMC Article
    5. Cyclic nucleotide phosphodiesterase of Dictyostelium discoideum and its glycoprotein inhibitor: structure and expression of their genes. Franke J, et al. Dev Genet, 1991. PMID 2049870

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cAMP phosphodiesterase PdsA and its inhibitor PdiA, which are essential for cAMP wave propagation
      Title: Evolution of self-organisation in Dictyostelia by adaptation of a non-selective phosphodiesterase and a matrix component for regulated cAMP degradation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by dictyBase

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cAMP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cAMP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cGMP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within aggregation involved in sorocarp development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within aggregation involved in sorocarp development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cAMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within extracellular regulation of signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of glucose mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to cAMP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to catechin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to differentiation-inducing factor 1 IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to dithiothreitol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within slug development involved in sorocarp development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cAMP phosphodiesterase
    Names
    cGMP phosphodiesterase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_007090.3 Reference assembly

      Range
      3929775..3931286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_632856.1 → XP_637948.1  cAMP phosphodiesterase [Dictyostelium discoideum AX4]

      See identical proteins and their annotated locations for XP_637948.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P12019, Q54ME9
      Conserved Domains (1) summary
      pfam02112
      Location:76 → 447
      PDEase_II; cAMP phosphodiesterases class-II
    Nucleotide Protein
    Heading Accession and Version

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