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    Tinagl1 tubulointerstitial nephritis antigen-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 94174, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tinagl1provided by RGD
    Official Full Name
    tubulointerstitial nephritis antigen-like 1provided by RGD
    Primary source
    RGD:70956
    See related
    EnsemblRapid:ENSRNOG00000013179 AllianceGenome:RGD:70956
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lcn7; gis5
    Summary
    Predicted to enable laminin binding activity. Predicted to be involved in proteolysis. Predicted to be located in cytoplasm. Predicted to be active in extracellular space and lysosome. Orthologous to human TINAGL1 (tubulointerstitial nephritis antigen like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 325.7), Lung (RPKM 138.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tinagl1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (147797884..147807925, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (142513710..142523730, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (148382702..148392729, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene penta-EF hand domain containing 1 Neighboring gene hypocretin receptor 1 Neighboring gene leucine decarboxylase 1 Neighboring gene uncharacterized LOC120102988

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung. Favre CJ, et al. Am J Physiol Heart Circ Physiol, 2003 Nov. PMID 12842817
    2. TIN-ag-RP, a novel catalytically inactive cathepsin B-related protein with EGF domains, is predominantly expressed in vascular smooth muscle cells. Wex T, et al. Biochemistry, 2001 Feb 6. PMID 11170462
    3. Cloning, characterization, and expression of the human TIN-ag-RP gene encoding a novel putative extracellular matrix protein. Brömme NC, et al. Biochem Biophys Res Commun, 2000 May 10. PMID 10799322
    4. Tubulointerstitial nephritis antigen-like 1 is expressed in extraembryonic tissues and interacts with laminin 1 in the Reichert membrane at postimplantation in the mouse. Igarashi T, et al. Biol Reprod, 2009 Nov. PMID 19587330
    5. Isolation of an androgen-inducible novel lipocalin gene, Arg1, from androgen-dependent mouse mammary Shionogi carcinoma cells. Kobayashi M, et al. J Steroid Biochem Mol Biol, 2001 May. PMID 11377975

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables cysteine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables laminin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables laminin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tubulointerstitial nephritis antigen-like
    Names
    glucocorticoid-inducible protein 5
    lipocalin 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433752.1 → NP_001420681.1  tubulointerstitial nephritis antigen-like precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q9EQT5
      UniProtKB/TrEMBL
      A6ISN5, F7F528, Q4V8N0

    2. NM_053582.3 → NP_446034.2  tubulointerstitial nephritis antigen-like precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q9EQT5
      UniProtKB/TrEMBL
      A6ISN5, F7F528, Q4V8N0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      147797884..147807925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238977.5 → XP_006239039.1  tubulointerstitial nephritis antigen-like isoform X1

      Conserved Domains (2) summary
      cd02620
      Location:203 → 455
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      cl02508
      Location:53 → 93
      Somatomedin_B; Somatomedin B domain

    2. XM_006238978.5 → XP_006239040.1  tubulointerstitial nephritis antigen-like isoform X1

      Related
      ENSRNOP00000018464.3, ENSRNOT00000018464.7
      Conserved Domains (2) summary
      cd02620
      Location:203 → 455
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      cl02508
      Location:53 → 93
      Somatomedin_B; Somatomedin B domain

    3. XM_039110893.2 → XP_038966821.1  tubulointerstitial nephritis antigen-like isoform X1

      UniProtKB/Swiss-Prot
      Q9EQT5
      UniProtKB/TrEMBL
      A6ISN5, F7F528, Q4V8N0
      Conserved Domains (2) summary
      cd02620
      Location:203 → 455
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      cl02508
      Location:53 → 93
      Somatomedin_B; Somatomedin B domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EQT5.1 GenPept UniProtKB/Swiss-Prot:Q9EQT5

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