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    CEACAM7 CEA cell adhesion molecule 7 [ Homo sapiens (human) ]

    Gene ID: 1087, updated on 27-Nov-2024

    Summary

    Official Symbol
    CEACAM7provided by HGNC
    Official Full Name
    CEA cell adhesion molecule 7provided by HGNC
    Primary source
    HGNC:HGNC:1819
    See related
    Ensembl:ENSG00000007306 MIM:619160; AllianceGenome:HGNC:1819
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGM2
    Summary
    This gene encodes a cell surface glycoprotein and member of the carcinoembryonic antigen (CEA) family of proteins. Expression of this gene may be downregulated in colon and rectal cancer. Additionally, lower expression levels of this gene may be predictive of rectal cancer recurrence. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
    Expression
    Restricted expression toward colon (RPKM 448.6) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CEACAM7 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41673303..41688270, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44492598..44507564, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42177231..42192199, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372405 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10670 Neighboring gene CEA cell adhesion molecule 5 Neighboring gene uncharacterized LOC112268252 Neighboring gene CEA cell adhesion molecule 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    carcinoembryonic antigen-related cell adhesion molecule 7
    Names
    carcinoembryonic antigen CGM2
    carcinoembryonic antigen gene family member 2
    carcinoembryonic antigen related cell adhesion molecule 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291485.2NP_001278414.1  carcinoembryonic antigen-related cell adhesion molecule 7 preproprotein

      See identical proteins and their annotated locations for NP_001278414.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC243960, AK292213
      Consensus CDS
      CCDS12583.1
      UniProtKB/Swiss-Prot
      A8K848, O15148, O15149, Q0VAC1, Q13983, Q14002, Q9UPJ2
      UniProtKB/TrEMBL
      B4DKM4
      Related
      ENSP00000385932.1, ENST00000401731.6
      Conserved Domains (2) summary
      cd05774
      Location:38141
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cl11960
      Location:147234
      Ig; Immunoglobulin domain
    2. NM_006890.5NP_008821.2  carcinoembryonic antigen-related cell adhesion molecule 7 preproprotein

      See identical proteins and their annotated locations for NP_008821.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC243960, BC121132, DC345133
      Consensus CDS
      CCDS12583.1
      UniProtKB/Swiss-Prot
      A8K848, O15148, O15149, Q0VAC1, Q13983, Q14002, Q9UPJ2
      UniProtKB/TrEMBL
      B4DKM4
      Related
      ENSP00000006724.3, ENST00000006724.7
      Conserved Domains (2) summary
      cd05774
      Location:38141
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cl11960
      Location:147234
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      41673303..41688270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187620.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      4498..8698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      44492598..44507564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)