ec echinus [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ecprovided by FlyBase
Official Full Name: echinusprovided by FlyBase
Primary source: FLYBASE:FBgn0000542
Locus tag: Dmel_CG2904
See related: AllianceGenome:FB:FBgn0000542
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2904; Dmel\CG2904; Ec; EG:EG0002.3; Q1W9Q0
Summary: Enables protein phosphatase 1 binding activity. Involved in compound eye retinal cell programmed cell death; ommatidial rotation; and positive regulation of compound eye retinal cell programmed cell death. Is expressed in cone cell; interommatidial precursor cell; primary pigment cell; and retina. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to several human genes including USP54 (ubiquitin specific peptidase 54). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 3F2-3F3; 1-5 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (3811698..3857621)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (3705731..3751654)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a new allele of echinus was isolated; findings show that echinus displays defects in the rotation of ommatidia that are not evident until mid-pupal stages, and we propose that echinus action is that of opposing EGFR
Title: A new allele uncovers the role of echinus in the control of ommatidial rotation in the Drosophila eye.
The echinus locus encodes multiple splice forms of a protein with homology to ubiquitin-specific proteases, but protease activity is unlikely to be required for echinus function, at least when echinus is overexpressed.
Title: echinus, required for interommatidial cell sorting and cell death in the Drosophila pupal retina, encodes a protein with homology to ubiquitin-specific proteases.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0121 (e-PCR)
- UniSTS:5482

Dm0122 (e-PCR)
- UniSTS:56559

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
NOT enables cysteine-type deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables peptidase activity	IKR Inferred from Key Residues more info
enables protein phosphatase 1 binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in compound eye retinal cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ommatidial rotation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of compound eye retinal cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein deubiquitination	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: echinus

Names: CG2904-PA; CG2904-PB; CG2904-PC; ec-PA; ec-PB; ec-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

3811698..3857621

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_130722.4 → NP_570078.2 echinus, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_570078.2

Status: REVIEWED

UniProtKB/TrEMBL

Q1W9Q0, Q7K7E6

Conserved Domains (3) summary

cd02257
Location:164 → 391

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

cl02553
Location:75 → 220

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:76 → 391

UCH; Ubiquitin carboxyl-terminal hydrolase
NM_166992.3 → NP_726893.2 echinus, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726893.2

Status: REVIEWED

UniProtKB/TrEMBL

O77283, Q6PV58, Q7K7E6

Conserved Domains (2) summary

cd02257
Location:130 → 357

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:49 → 357

UCH; Ubiquitin carboxyl-terminal hydrolase
NM_001103407.3 → NP_001096877.1 echinus, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001096877.1

Status: REVIEWED

UniProtKB/TrEMBL

Q1W9P9, Q7K7E6

Conserved Domains (1) summary

cd02257
Location:183 → 410

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...