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    Ssadh Succinic semialdehyde dehydrogenase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43092, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ssadhprovided by FlyBase
    Official Full Name
    Succinic semialdehyde dehydrogenaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039349
    Locus tag
    Dmel_CG4685
    See related
    AllianceGenome:FB:FBgn0039349
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.428; CG4685; Dmel\CG4685; DmSSADH; Q9VBP6; ssadh; SSADH
    Summary
    Enables succinate-semialdehyde dehydrogenase (NAD+) activity. Predicted to be involved in gamma-aminobutyric acid catabolic process. Predicted to be active in mitochondrion. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in succinic semialdehyde dehydrogenase deficiency. Orthologous to human ALDH5A1 (aldehyde dehydrogenase 5 family member A1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ssadh in Genome Data Viewer
    Location:
    96E6-96E6; 3-88 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25624805..25626924, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21450527..21452646, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Nuclear protein localization 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene jing interacting gene regulatory 1 Neighboring gene mir-92a stem loop Neighboring gene long non-coding RNA:CR45917 Neighboring gene mir-92b stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of a Drosophila melanogaster succinic semialdehyde dehydrogenase and a non-specific aldehyde dehydrogenase. Rothacker B, et al. Insect Biochem Mol Biol, 2008 Mar. PMID 18252249
    2. Saturation transfer difference NMR studies on substrates and inhibitors of succinic semialdehyde dehydrogenases. Jaeger M, et al. Biochem Biophys Res Commun, 2008 Aug 1. PMID 18474219
    3. Metabolic control of cellular immune-competency by odors in Drosophila. Madhwal S, et al. Elife, 2020 Dec 29. PMID 33372660, Free PMC Article
    4. Segmental duplication, microinversion, and gene loss associated with a complex inversion breakpoint region in Drosophila. Calvete O, et al. Mol Biol Evol, 2012 Jul. PMID 22328714, Free PMC Article
    5. Independent Effects of γ-Aminobutyric Acid Transaminase (GABAT) on Metabolic and Sleep Homeostasis. Maguire SE, et al. J Biol Chem, 2015 Aug 14. PMID 26124278, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables succinate-semialdehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate-semialdehyde dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables succinate-semialdehyde dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables succinate-semialdehyde dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in gamma-aminobutyric acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gamma-aminobutyric acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gamma-aminobutyric acid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    succinic semialdehyde dehydrogenase
    Names
    CG4685-PA
    CG4685-PB
    CG4685-PC
    CG4685-PD
    CG4685-PE
    Ssadh-PA
    Ssadh-PB
    Ssadh-PC
    Ssadh-PD
    Ssadh-PE
    Succinate-semialdehyde dehydrogenase
    NP_001014665.1
    NP_001014666.1
    NP_001014667.1
    NP_001163732.1
    NP_651408.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25624805..25626924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170261.2 → NP_001163732.1  succinic semialdehyde dehydrogenase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163732.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBP6
      Conserved Domains (1) summary
      cd07103
      Location:49 → 503
      ALDH_F5_SSADH_GabD; Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like

    2. NM_001014665.2 → NP_001014665.1  succinic semialdehyde dehydrogenase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014665.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBP6
      Conserved Domains (1) summary
      cd07103
      Location:49 → 503
      ALDH_F5_SSADH_GabD; Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like

    3. NM_001014666.3 → NP_001014666.1  succinic semialdehyde dehydrogenase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014666.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBP6
      Conserved Domains (1) summary
      cd07103
      Location:49 → 503
      ALDH_F5_SSADH_GabD; Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like

    4. NM_001014667.3 → NP_001014667.1  succinic semialdehyde dehydrogenase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014667.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBP6
      Conserved Domains (1) summary
      cd07103
      Location:49 → 503
      ALDH_F5_SSADH_GabD; Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like

    5. NM_143151.3 → NP_651408.1  succinic semialdehyde dehydrogenase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651408.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBP6
      Related
      FBpp0084265
      Conserved Domains (1) summary
      cd07103
      Location:49 → 503
      ALDH_F5_SSADH_GabD; Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBP6 Q9VBP6

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