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    AZIN1 antizyme inhibitor 1 [ Myotis brandtii (Brandt's bat) ]

    Gene ID: 102240580, updated on 30-Mar-2024

    Summary

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    Gene symbol
    AZIN1
    Gene description
    antizyme inhibitor 1
    Locus tag
    D623_10032166
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Myotis brandtii
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yangochiroptera; Vespertilionidae; Myotis
    Summary
    The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
    Orthologs
    human mouse all
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    Genomic context

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    See AZIN1 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    101 current ASM41265v1 (GCF_000412655.1) Unplaced Scaffold NW_005370223.1 (6226167..6260558, complement)

    NW_005370223.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106728308 Neighboring gene uncharacterized LOC106728328 Neighboring gene ATPase H+ transporting V1 subunit C1 Neighboring gene uncharacterized LOC106728326

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_005370223.1 Unplaced Scaffold Reference ASM41265v1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of cellular polyamine levels and cellular proliferation by antizyme and antizyme inhibitor. Kahana C. Essays Biochem, 2009 Nov 4. PMID 20095969
    2. Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii. Seim I, et al. Nat Commun, 2013. PMID 23962925, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ornithine decarboxylase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ornithine decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of polyamine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in putrescine biosynthetic process from ornithine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    antizyme inhibitor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291714.1 → NP_001278643.1  antizyme inhibitor 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      ANKR01282387, ANKR01282388
      UniProtKB/TrEMBL
      S7NEM6
      Conserved Domains (2) summary
      cd06831
      Location:26 → 419
      PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor
      COG0019
      Location:40 → 405
      LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]

    2. NM_001301794.1 → NP_001288723.1  antizyme inhibitor 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site in the 3' coding region compared to variant 1. The resulting isoform (2) is 1 aa shorter than isoform 1.
      Source sequence(s)
      ANKR01282387, ANKR01282388
      UniProtKB/TrEMBL
      S7NEM6
      Conserved Domains (2) summary
      cd06831
      Location:26 → 418
      PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor
      COG0019
      Location:40 → 404
      LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]

    RefSeqs of Annotated Genomes: Myotis brandtii Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM41265v1

    Genomic

    1. NW_005370223.1 Reference ASM41265v1

      Range
      6226167..6260558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014550197.1 → XP_014405683.1  antizyme inhibitor 1 isoform X1

      UniProtKB/TrEMBL
      S7NEM6
      Conserved Domains (2) summary
      cd06831
      Location:26 → 419
      PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor
      COG0019
      Location:40 → 405
      LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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