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    Myzap myocardial zonula adherens protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363091, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Myzapprovided by RGD
    Official Full Name
    myocardial zonula adherens proteinprovided by RGD
    Primary source
    RGD:1359197
    See related
    EnsemblRapid:ENSRNOG00000071258 AllianceGenome:RGD:1359197
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gcom1
    Summary
    Predicted to enable transcription elongation factor activity. Predicted to be involved in intracellular signal transduction. Located in cytoskeleton and membrane. Orthologous to several human genes including MYZAP (myocardial zonula adherens protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 1588.9), Lung (RPKM 415.1) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myzap in Genome Data Viewer
    Location:
    8q24
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (81036599..81123933, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (72155817..72243036, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (78009019..78096409, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480072 Neighboring gene uncharacterized LOC120094203 Neighboring gene RNA polymerase II subunit M Neighboring gene dynein light chain LC8-type 1, pseudogene 1 Neighboring gene cingulin-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GRINL1A colocalizes with N-methyl D-aspartate receptor NR1 subunit and reduces N-methyl D-aspartate toxicity. Roginski RS, et al. Neuroreport, 2008 Nov 19. PMID 18849881
    2. Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo. Seeger TS, et al. Circ Res, 2010 Mar 19. PMID 20093627, Free PMC Article
    3. Rho-family GTPase 1 (Rnd1) is a biomechanical stress-sensitive activator of cardiomyocyte hypertrophy. Kluge A, et al. J Mol Cell Cardiol, 2019 Apr. PMID 30797814
    4. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109137

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in I band IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in I band ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in I band ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cortical actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myocardial zonula adherens protein
    Names
    GRINL1A combined protein
    GRINL1A complex locus 1
    GRINL1A complex locus protein 1
    myozap

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014211.1 → NP_001014233.1  myocardial zonula adherens protein precursor

      See identical proteins and their annotated locations for NP_001014233.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089899
      UniProtKB/Swiss-Prot
      Q5EB94
      UniProtKB/TrEMBL
      A0A8I6AQM6, A6KER0
      Related
      ENSRNOP00000110374.1, ENSRNOT00000121939.1
      Conserved Domains (2) summary
      cd16269
      Location:277 → 290
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:205 → 310
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      81036599..81123933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081753.2 → XP_038937681.1  myocardial zonula adherens protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQM6
      Conserved Domains (1) summary
      COG1196
      Location:94 → 378
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_017595740.3 → XP_017451229.1  myocardial zonula adherens protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6AQM6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5EB94.1 GenPept UniProtKB/Swiss-Prot:Q5EB94

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials