btl breathless [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: btlprovided by FlyBase
Official Full Name: breathlessprovided by FlyBase
Primary source: FLYBASE:FBgn0285896
Locus tag: Dmel_CG32134
See related: AllianceGenome:FB:FBgn0285896
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0844/01; Btl; BTL; BTL/FGFR2; CG32134; CG6714; CT20816; D-FGFR; dev; DFGF-R1; dFGFR; Dfr-2; DFR2; Dmel\CG32134; DmHD-311; dtk2; Dtk2; fgf-r; Fgf-r; Fgfr; FGFR; FGFR1; HD-311; l(3)00208; l(3)j2E11; Tk2
Summary: Enables fibroblast growth factor receptor activity. Involved in several processes, including border follicle cell migration; negative regulation of cell differentiation; and open tracheal system development. Located in plasma membrane. Colocalizes with cytoneme. Is expressed in several structures, including abdominal tracheal metamere; epithelium; imaginal disc; primary segmental tracheal branch primordium; and tracheal system. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); gastrointestinal system cancer (multiple); osteochondrodysplasia (multiple); and synostosis (multiple). Orthologous to human FGFR2 (fibroblast growth factor receptor 2); FGFR3 (fibroblast growth factor receptor 3); and FGFR4 (fibroblast growth factor receptor 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 70D2-70D2; 3-42 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (14075772..14083229)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (14068872..14076329)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Time lapse imaging shows dynamic reorganization of branchless (bnl)-expressing cells and bnl-receptor breathless (btl) expressing trachea during embryonic development.
Title: Unique patterns of organization and migration of FGF-expressing cells during Drosophila morphogenesis.
Transgene expression of Drosophila melanogaster nucleoside kinase reverses mitochondrial thymidine kinase 2 deficiency
Title: Transgene expression of Drosophila melanogaster nucleoside kinase reverses mitochondrial thymidine kinase 2 deficiency.
Study demonstrates that jing is required for btl expression in the branching trachea and dominantly interacts with known regulators of btl expression, including the ETS and POU transcription factors, pointed, and drifter/ventral veinless, respectively
Title: Drosophila Jing is part of the breathless fibroblast growth factor receptor positive feedback loop.
Branchless/Breathless signaling contains a positive feedback loop, which may guarantee a continuous supply of fresh receptors to membranes of growing tracheal branch cells
Title: Ligand-dependent activation of breathless FGF receptor gene in Drosophila developing trachea.
Data show that Downstream-of-FGFR is a substrate for fibroblast growth factor receptors (FGFRs) and recruits Corkscrew, leading to FGF-induced cell migration and activation of the Ras/MAPK pathway.
Title: Downstream-of-FGFR is a fibroblast growth factor-specific scaffolding protein and recruits Corkscrew upon receptor activation.
In embryos, Fgfr1c was detected in osteoblasts of calvarial and mandibular bones. Fgfr3b and Fgfr3c were in chondrocytes in cranial base and mandibular condyle. Fgfr2b transcripts were detected in perichondria of mandibular condyle and cranial base.
Title: Fgfr mRNA isoforms in craniofacial bone development.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0354 (e-PCR)
- UniSTS:8475

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables fibroblast growth factor receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables fibroblast growth factor receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branch fusion, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching involved in open tracheal system development	IDA Inferred from Direct Assay more info	PubMed
involved_in branching involved in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell type specification, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in genital disc development	IEP Inferred from Expression Pattern more info	PubMed
involved_in glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lumen formation, open tracheal system	IGI Inferred from Genetic Interaction more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of crystal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of plasmatocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IEP Inferred from Expression Pattern more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of melanization defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in primary branching, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in secondary branching, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal branching, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal cell fate specification, open tracheal system	HMP more info	PubMed
involved_in terminal cell fate specification, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trachea development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tracheal outgrowth, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tracheal pit formation in open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with cytoneme	IDA Inferred from Direct Assay more info	PubMed
located_in cytoneme	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: breathless

Names: CG32134-PA; CG32134-PB; FGF receptor; FGFR; Fibroblast-growth-factor-receptor; btl-PA; btl-PB; devenir; fibrobast growth factor receptor; fibroblast growth factor receptor; fibroblast growth factor receptor 1; lethal (3) j2E11; no terminal cell clones-L

NP_001014583.1

EC 2.7.10.1

NP_729956.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

14075772..14083229

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_168577.3 → NP_729956.1 breathless, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729956.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1Y3, Q09147, Q712V2, Q9VUC8

UniProtKB/TrEMBL

D0IQ92

Related

FBpp0075520

Conserved Domains (8) summary

cd00096
Location:258 → 340

Ig; Immunoglobulin domain

smart00219
Location:712 → 996

TyrKc; Tyrosine kinase, catalytic domain

smart00408
Location:408 → 469

IGc2; Immunoglobulin C-2 Type

smart00409
Location:247 → 336

IG; Immunoglobulin

smart00410
Location:492 → 583

IG_like; Immunoglobulin like

pfam07679
Location:394 → 479

I-set; Immunoglobulin I-set domain

cl11960
Location:507 → 583

Ig; Immunoglobulin domain

cl21453
Location:700 → 1000

PKc_like; Protein Kinases, catalytic domain
NM_001014583.2 → NP_001014583.1 breathless, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014583.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V1Y3, Q09147, Q712V2, Q9VUC8

UniProtKB/TrEMBL

D0IQ92

Conserved Domains (8) summary

cd00096
Location:258 → 340

Ig; Immunoglobulin domain

smart00219
Location:712 → 996

TyrKc; Tyrosine kinase, catalytic domain

smart00408
Location:408 → 469

IGc2; Immunoglobulin C-2 Type

smart00409
Location:247 → 336

IG; Immunoglobulin

smart00410
Location:492 → 583

IG_like; Immunoglobulin like

pfam07679
Location:394 → 479

I-set; Immunoglobulin I-set domain

cl11960
Location:507 → 583

Ig; Immunoglobulin domain

cl21453
Location:700 → 1000

PKc_like; Protein Kinases, catalytic domain