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    btsz bitesize [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3346167, updated on 9-Dec-2024

    Summary

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    Official Symbol
    btszprovided by FlyBase
    Official Full Name
    bitesizeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0266756
    Locus tag
    Dmel_CG44012
    See related
    AllianceGenome:FB:FBgn0266756
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH06647; Btsz; CG14858; CG17304; CG18280; CG31306; CG33555; CG44012; CG7343; Dmel\CG44012; Granulophilin; l(3)10418
    Old locus tag
    Dmel_CG17304; Dmel_CG33555
    Summary
    Predicted to enable neurexin family protein binding activity. Involved in several processes, including actin cytoskeleton organization; embryonic morphogenesis; and larval salivary gland morphogenesis. Located in apical plasma membrane. Is expressed in several structures, including adult head; dorsal ectoderm; dorsal ectoderm anlage; epithelium; and gut section. Orthologous to human SYTL1 (synaptotagmin like 1); SYTL4 (synaptotagmin like 4); and SYTL5 (synaptotagmin like 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See btsz in Genome Data Viewer
    Location:
    88D4-88D6; 3-56 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14804092..14875488, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10629814..10701210, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46024 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rrp6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila synaptotagmin-like protein bitesize is required for growth and has mRNA localization sequences within its open reading frame. Serano J, et al. Proc Natl Acad Sci U S A, 2003 Nov 11. PMID 14581614, Free PMC Article
    2. Re-solving the cadherin-catenin-actin conundrum. Weis WI, et al. J Biol Chem, 2006 Nov 24. PMID 17005550, Free PMC Article
    3. CTCF, BEAF-32, and CP190 are not required for the establishment of TADs in early Drosophila embryos but have locus-specific roles. Cavalheiro GR, et al. Sci Adv, 2023 Feb 3. PMID 36735786, Free PMC Article
    4. An endosome-associated actin network involved in directed apical plasma membrane growth. Ríos-Barrera LD, et al. J Cell Biol, 2022 Mar 7. PMID 35061016, Free PMC Article
    5. Spatial control of actin organization at adherens junctions by a synaptotagmin-like protein Btsz. Pilot F, et al. Nature, 2006 Aug 3. PMID 16862128

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Btsz and Moesin guide luminal membrane morphogenesis through organizing actin.
      Title: Guidance of subcellular tubulogenesis by actin under the control of a synaptotagmin-like protein and Moesin.
    2. found that bitesize is a metazoan example of a transcript for which all identifiable mRNA localization sequences are contained within the protein-coding region
      Title: The Drosophila synaptotagmin-like protein bitesize is required for growth and has mRNA localization sequences within its open reading frame.
    3. data indicate that, through their interaction, Btsz and Moesin may mediate the proper organization of actin in a local domain, which in turn stabilizes E-cadherin
      Title: Spatial control of actin organization at adherens junctions by a synaptotagmin-like protein Btsz.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables neurexin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in apical junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cortical actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of planar polarity of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gastrulation involving germ band extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in larval salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lumen formation, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bitesize
    Names
    CG44012-PB
    CG44012-PC
    CG44012-PD
    CG44012-PE
    CG44012-PF
    CG44012-PG
    CG44012-PH
    CG44012-PI
    CG44012-PJ
    bite size
    btsz-PB
    btsz-PC
    btsz-PD
    btsz-PE
    btsz-PF
    btsz-PG
    btsz-PH
    btsz-PI
    btsz-PJ
    granulophilin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14804092..14875488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014622.3 → NP_001014622.3  bitesize, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014622.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59DX2
      Conserved Domains (4) summary
      cd04020
      Location:1367 → 1556
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08521
      Location:1231 → 1353
      C2A_SLP; C2 domain first repeat present in Synaptotagmin-like proteins
      cd15747
      Location:239 → 286
      FYVE_Slp3_4_5; FYVE-related domain found in the synaptotagmin-like proteins 3, 4, 5
      pfam15279
      Location:514 → 689
      SOBP; Sine oculis-binding protein

    2. NM_001275653.1 → NP_001262582.1  bitesize, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262582.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59DX2
      Conserved Domains (4) summary
      cd04020
      Location:1367 → 1556
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08521
      Location:1231 → 1353
      C2A_SLP; C2 domain first repeat present in Synaptotagmin-like proteins
      cd15747
      Location:239 → 286
      FYVE_Slp3_4_5; FYVE-related domain found in the synaptotagmin-like proteins 3, 4, 5
      pfam15279
      Location:514 → 689
      SOBP; Sine oculis-binding protein

    3. NM_001014625.3 → NP_001014625.1  bitesize, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014625.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6XK20
      Conserved Domains (3) summary
      cd04020
      Location:902 → 1091
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08521
      Location:766 → 888
      C2A_SLP; C2 domain first repeat present in Synaptotagmin-like proteins
      pfam15279
      Location:49 → 224
      SOBP; Sine oculis-binding protein

    4. NM_001144584.3 → NP_001138056.1  bitesize, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138056.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0K1
      Conserved Domains (3) summary
      cd04020
      Location:937 → 1126
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08521
      Location:801 → 923
      C2A_SLP; C2 domain first repeat present in Synaptotagmin-like proteins
      pfam15279
      Location:49 → 224
      SOBP; Sine oculis-binding protein

    5. NM_001260180.2 → NP_001247109.1  bitesize, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247109.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K657
      Conserved Domains (4) summary
      cd04020
      Location:3534 → 3723
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08521
      Location:3398 → 3520
      C2A_SLP; C2 domain first repeat present in Synaptotagmin-like proteins
      cd15747
      Location:26 → 73
      FYVE_Slp3_4_5; FYVE-related domain found in the synaptotagmin-like proteins 3, 4, 5
      pfam15279
      Location:300 → 476
      SOBP; Sine oculis-binding protein

    6. NM_001014624.3 → NP_001014624.1  bitesize, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014624.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6XK19
      Conserved Domains (2) summary
      cd04020
      Location:2445 → 2634
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08521
      Location:2309 → 2431
      C2A_SLP; C2 domain first repeat present in Synaptotagmin-like proteins

    7. NM_001014623.3 → NP_001014623.1  bitesize, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014623.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59DW9, Q6XK18
      Conserved Domains (2) summary
      cd04020
      Location:1317 → 1506
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08521
      Location:1181 → 1303
      C2A_SLP; C2 domain first repeat present in Synaptotagmin-like proteins

    8. NM_001144583.3 → NP_001138055.1  bitesize, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138055.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0K2, Q1EBZ7
      Conserved Domains (2) summary
      cd04020
      Location:400 → 589
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08521
      Location:264 → 386
      C2A_SLP; C2 domain first repeat present in Synaptotagmin-like proteins

    9. NM_001104324.4 → NP_001097794.1  bitesize, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097794.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JR10
      Conserved Domains (2) summary
      cd04020
      Location:508 → 697
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd08521
      Location:372 → 494
      C2A_SLP; C2 domain first repeat present in Synaptotagmin-like proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K657 A0A0B4K657
    A8JR10 A8JR10
    B7Z0K1 B7Z0K1
    B7Z0K2 B7Z0K2
    Q2XYH6 Q2XYH6
    Q59DW9 Q59DW9
    Q59DX2 Q59DX2
    Q6XK18 Q6XK18
    Q6XK19 Q6XK19
    Q6XK20 Q6XK20
    Q8MSJ8 Q8MSJ8

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