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    ppk20 pickpocket 20 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43486, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppk20provided by FlyBase
    Official Full Name
    pickpocket 20provided by FlyBase
    Primary source
    FLYBASE:FBgn0039676
    Locus tag
    Dmel_CG7577
    See related
    AllianceGenome:FB:FBgn0039676
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7577; Dmel\CG7577; Ppk20; PPK20
    Summary
    Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in wing disc. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ppk20 in Genome Data Viewer
    Location:
    99B6-99B7; 3-99 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29666814..29668877, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25492536..25494599, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Dopamine 1-like receptor 2 Neighboring gene pickpocket 21 Neighboring gene pickpocket 30 Neighboring gene Odorant-binding protein 99a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two Drosophila DEG/ENaC channel subunits have distinct functions in gustatory neurons that activate male courtship. Liu T, et al. J Neurosci, 2012 Aug 22. PMID 22915128, Free PMC Article
    2. Drosophila DEG/ENaC pickpocket genes are expressed in the tracheal system, where they may be involved in liquid clearance. Liu L, et al. Proc Natl Acad Sci U S A, 2003 Feb 18. PMID 12571352, Free PMC Article
    3. Contribution of Drosophila DEG/ENaC genes to salt taste. Liu L, et al. Neuron, 2003 Jul 3. PMID 12848938
    4. ppk23-Dependent chemosensory functions contribute to courtship behavior in Drosophila melanogaster. Lu B, et al. PLoS Genet, 2012. PMID 22438833, Free PMC Article
    5. A map of sensilla and neurons in the taste system of drosophila larvae. Rist A, et al. J Comp Neurol, 2017 Dec 15. PMID 28842919

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pickpocket 20
    Names
    CG7577-PA
    CG7577-PB
    CG7577-PC
    ppk20-PA
    ppk20-PB
    ppk20-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29666814..29668877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276145.1 → NP_001263074.1  pickpocket 20, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263074.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHD5
      Conserved Domains (1) summary
      pfam00858
      Location:34 → 498
      ASC; Amiloride-sensitive sodium channel

    2. NM_001276146.1 → NP_001263075.1  pickpocket 20, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263075.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHV2
      Conserved Domains (1) summary
      pfam00858
      Location:34 → 499
      ASC; Amiloride-sensitive sodium channel

    3. NM_143448.2 → NP_651705.2  pickpocket 20, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651705.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAJ6
      Conserved Domains (1) summary
      pfam00858
      Location:34 → 521
      ASC; Amiloride-sensitive sodium channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHD5 A0A0B4KHD5
    A0A0B4KHV2 A0A0B4KHV2
    Q86LG5 Q86LG5
    Q9VAJ6 Q9VAJ6

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