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    Ankrd46 ankyrin repeat domain 46 [ Mus musculus (house mouse) ]

    Gene ID: 68839, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ankrd46provided by MGI
    Official Full Name
    ankyrin repeat domain 46provided by MGI
    Primary source
    MGI:MGI:1916089
    See related
    Ensembl:ENSMUSG00000048307 AllianceGenome:MGI:1916089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110054N06Rik
    Summary
    Predicted to be located in membrane. Is expressed in nervous system. Orthologous to human ANKRD46 (ankyrin repeat domain 46). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 35.6), bladder adult (RPKM 34.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ankrd46 in Genome Data Viewer
    Location:
    15 B3.1; 15 14.47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (36477814..36496937, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (36477668..36496791, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38358 Neighboring gene predicted gene, 34150 Neighboring gene predicted gene, 34093 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:36390760-36390961 Neighboring gene STARR-seq mESC enhancer starr_38360 Neighboring gene predicted gene, 34316 Neighboring gene sorting nexin 31 Neighboring gene STARR-seq mESC enhancer starr_38361 Neighboring gene STARR-seq mESC enhancer starr_38364 Neighboring gene poly(A) binding protein, cytoplasmic 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MicroRNA-451 plays a role in murine embryo implantation through targeting Ankrd46, as implicated by a microarray-based analysis. Li Z, et al. Fertil Steril, 2015 Mar. PMID 25542822
    2. Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse. Brouns MR, et al. Hum Mol Genet, 2011 Apr 15. PMID 21262862, Free PMC Article
    3. Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development. Silvestri C, et al. Dev Cell, 2008 Mar. PMID 18331719
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-451 was specifically up-regulated during the implantation period, and it may play a major role in embryo implantation by targeting Ankrd46.
      Title: MicroRNA-451 plays a role in murine embryo implantation through targeting Ankrd46, as implicated by a microarray-based analysis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 46
    Names
    ANK-S
    ankyrin repeat small protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358006.1 → NP_001344935.1  ankyrin repeat domain-containing protein 46

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC137871, AC158986
      Consensus CDS
      CCDS27429.1
      UniProtKB/Swiss-Prot
      Q1LZK9, Q8BTZ5, Q8BV97
      Conserved Domains (2) summary
      COG0666
      Location:15 → 148
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:15 → 42
      ANK; ANK repeat [structural motif]

    2. NM_001358007.1 → NP_001344936.1  ankyrin repeat domain-containing protein 46

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC137871, AC158986
      Consensus CDS
      CCDS27429.1
      UniProtKB/Swiss-Prot
      Q1LZK9, Q8BTZ5, Q8BV97
      Conserved Domains (2) summary
      COG0666
      Location:15 → 148
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:15 → 42
      ANK; ANK repeat [structural motif]

    3. NM_175134.4 → NP_780343.1  ankyrin repeat domain-containing protein 46

      See identical proteins and their annotated locations for NP_780343.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC035553, BQ715954
      Consensus CDS
      CCDS27429.1
      UniProtKB/Swiss-Prot
      Q1LZK9, Q8BTZ5, Q8BV97
      Related
      ENSMUSP00000052521.8, ENSMUST00000057486.9
      Conserved Domains (2) summary
      COG0666
      Location:15 → 148
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:15 → 42
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      36477814..36496937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BTZ5.1 GenPept UniProtKB/Swiss-Prot:Q8BTZ5

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