ILV6 acetolactate synthase regulatory subunit [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ILV6
Official Full Name: acetolactate synthase regulatory subunit
Primary source: SGD:S000000515
Locus tag: YCL009C
See related: AllianceGenome:SGD:S000000515; FungiDB:YCL009C; VEuPathDB:YCL009C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables enzyme regulator activity. Contributes to acetolactate synthase activity. Involved in branched-chain amino acid biosynthetic process. Located in mitochondrial nucleoid. Part of acetolactate synthase complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ILV6 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 1

Sequence:: Chromosome: III; NC_001135.5 (104619..105548, complement)

Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Using various soluble quinone derivatives (e.g. ubiquinones), this study reveals a new path of down-regulation of acetolactate synthase activity involving inhibition by oxidized redox-signaling molecules.
Title: The Role of a FAD Cofactor in the Regulation of Acetohydroxyacid Synthase by Redox Signaling Molecules.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to acetolactate synthase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to acetolactate synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables acetolactate synthase regulator activity	IEA Inferred from Electronic Annotation more info
enables enzyme regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme regulator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in L-valine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in branched-chain amino acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in branched-chain amino acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in branched-chain amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in isoleucine biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of acetolactate synthase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of acetolactate synthase complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial nucleoid	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial nucleoid	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: acetolactate synthase regulatory subunit

NP_009918.1

Regulatory subunit of acetolactate synthase; acetolactate synthase catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001135.5 Reference assembly

Range

104619..105548 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178658.1 → NP_009918.1 TPA: acetolactate synthase regulatory subunit [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009918.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VR03, P25605, P87009

UniProtKB/TrEMBL

A6ZTH5, B3LU66, C7GQK9, N1PAP6

Conserved Domains (1) summary

TIGR00119
Location:77 → 282

acolac_sm; acetolactate synthase, small subunit