SIR2 NAD-dependent histone deacetylase SIR2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SIR2
Official Full Name: NAD-dependent histone deacetylase SIR2
Primary source: SGD:S000002200
Locus tag: YDL042C
See related: AllianceGenome:SGD:S000002200; FungiDB:YDL042C; VEuPathDB:YDL042C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MAR1
Summary: Enables DNA replication origin binding activity and NAD-dependent histone deacetylase activity. Contributes to nucleosome binding activity. Involved in several processes, including establishment of protein-containing complex localization to telomere; negative regulation of macromolecule metabolic process; and regulation of DNA stability. Located in chromosome, telomeric region; heterochromatin; and nucleolus. Part of RENT complex. Used to study Alzheimer's disease; Parkinson's disease; diabetes mellitus; and prostate cancer. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human SIRT1 (sirtuin 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SIR2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (376757..378445, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sir2 and Reb1 antagonistically regulate nucleosome occupancy in subtelomeric X-elements and repress TERRAs by distinct mechanisms.
Title: Sir2 and Reb1 antagonistically regulate nucleosome occupancy in subtelomeric X-elements and repress TERRAs by distinct mechanisms.
Spreading-dependent or independent Sir2-mediated gene silencing in budding yeast.
Title: Spreading-dependent or independent Sir2-mediated gene silencing in budding yeast.
A novel allele of SIR2 reveals a heritable intermediate state of gene silencing.
Title: A novel allele of SIR2 reveals a heritable intermediate state of gene silencing.
Cell volume homeostatically controls the rDNA repeat copy number and rRNA synthesis rate in yeast.
Title: Cell volume homeostatically controls the rDNA repeat copy number and rRNA synthesis rate in yeast.
SIR2 Expression Noise Can Generate Heterogeneity in Viability but Does Not Affect Cell-to-Cell Epigenetic Silencing of Subtelomeric URA3 in Yeast.
Title: SIR2 Expression Noise Can Generate Heterogeneity in Viability but Does Not Affect Cell-to-Cell Epigenetic Silencing of Subtelomeric URA3 in Yeast.
TORC1 signaling regulates cytoplasmic pH through Sir2 in yeast.
Title: TORC1 signaling regulates cytoplasmic pH through Sir2 in yeast.
Evolution of Distinct Responses to Low NAD(+) Stress by Rewiring the Sir2 Deacetylase Network in Yeasts.
Title: Evolution of Distinct Responses to Low NAD(+) Stress by Rewiring the Sir2 Deacetylase Network in Yeasts.
Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence.
Title: Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence.
Sir2 mitigates an intrinsic imbalance in origin licensing efficiency between early- and late-replicating euchromatin.
Title: Sir2 mitigates an intrinsic imbalance in origin licensing efficiency between early- and late-replicating euchromatin.
It was believed the only role for Saccharomyces cerevisiae Sir2 in mating-type switching was silencing HML and HMR. Study shows that Sir2 also regulates expression of a small gene (RDT1) in the cis-acting DNA element called the recombination enhancer that is activated during mating-type switching.
Title: A Sir2-regulated locus control region in the recombination enhancer of Saccharomyces cerevisiae specifies chromosome III structure.

Submit: New GeneRIF Correction See all GeneRIFs (92)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA replication origin binding	IDA Inferred from Direct Assay more info	PubMed
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables NAD-dependent protein lysine deacetylase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K14 deacetylase activity, NAD-dependent	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K14 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K18 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K4 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K56 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K9 deacetylase activity, NAD-dependent	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K9 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H4K16 deacetylase activity, NAD-dependent	IBA Inferred from Biological aspect of Ancestor more info
enables histone H4K16 deacetylase activity, NAD-dependent	IDA Inferred from Direct Assay more info	PubMed
enables histone H4K16 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone deacetylase activity, NAD-dependent	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
contributes_to nucleosome binding	IDA Inferred from Direct Assay more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in double-strand break repair via nonhomologous end joining	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of protein-containing complex localization to telomere	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterochromatin formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA amplification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA recombination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of DNA recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rDNA heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mating type switching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in silent mating-type cassette heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in subtelomeric heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere tethering at nuclear periphery	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RENT complex	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin silencing complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	IMP Inferred from Mutant Phenotype more info	PubMed
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NAD-dependent histone deacetylase SIR2

NP_010242.1

EC 2.3.1.286

Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication, suppressing early firing of multicopy rDNA origins; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

376757..378445 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180101.1 → NP_010242.1 TPA: NAD-dependent histone deacetylase SIR2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010242.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRV4, P06700

UniProtKB/TrEMBL

B3LGU0, B5VFM5, C8Z4M8, N1P5V5

Conserved Domains (2) summary

cd01408
Location:255 → 517

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...

pfam04574
Location:104 → 261

DUF592; Protein of unknown function (DUF592)