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    LSM5 RNA-binding protein LSM5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856889, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LSM5
    Official Full Name
    RNA-binding protein LSM5
    Primary source
    SGD:S000000948
    Locus tag
    YER146W
    See related
    AllianceGenome:SGD:S000000948; FungiDB:YER146W; VEuPathDB:YER146W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleolus. Part of Lsm1-7-Pat1 complex; sno(s)RNA-containing ribonucleoprotein complex; and spliceosomal snRNP complex. Orthologous to human LSM5 (LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LSM5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (462585..462866)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene putative ubiquitin-specific protease UBP5 Neighboring gene high-affinity iron permease FTR1 Neighboring gene uncharacterized protein Neighboring gene cohesin-loading factor complex subunit SCC4 Neighboring gene TATA-binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of Lsm3 octamer from Saccharomyces cerevisiae: implications for Lsm ring organisation and recruitment. Naidoo N, et al. J Mol Biol, 2008 Apr 11. PMID 18329667
    2. Genetic interaction between a chaperone of small nucleolar ribonucleoprotein particles and cytosolic serine hydroxymethyltransferase. Yang Y, et al. J Biol Chem, 2003 Jun 27. PMID 12700234
    3. Characterization of U6 snRNA-protein interactions. Vidal VP, et al. RNA, 1999 Nov. PMID 10580475, Free PMC Article
    4. Lsm proteins are required for normal processing of pre-tRNAs and their efficient association with La-homologous protein Lhp1p. Kufel J, et al. Mol Cell Biol, 2002 Jul. PMID 12077351, Free PMC Article
    5. Nuclear pre-mRNA decapping and 5' degradation in yeast require the Lsm2-8p complex. Kufel J, et al. Mol Cell Biol, 2004 Nov. PMID 15485930, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Lsm1-7-Pat1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Lsm1-7-Pat1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U6 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U6 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U6 snRNP TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of sno(s)RNA-containing ribonucleoprotein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein LSM5
    NP_011073.1
    • Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      462585..462866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179036.1 → NP_011073.1  TPA: RNA-binding protein LSM5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011073.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM53, P40089
      UniProtKB/TrEMBL
      A6ZRA3, B3LRQ9, C7GQ50, C8Z7G7, G2WD33, N1P5D1
      Conserved Domains (1) summary
      cd01732
      Location:6 → 85
      LSm5; Like-Sm protein 5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40089.1

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