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    COG3 Golgi transport complex subunit COG3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856901, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COG3
    Official Full Name
    Golgi transport complex subunit COG3
    Primary source
    SGD:S000000959
    Locus tag
    YER157W
    See related
    AllianceGenome:SGD:S000000959; FungiDB:YER157W; VEuPathDB:YER157W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GRD20; SEC34
    Summary
    Enables cargo adaptor activity. Involved in Golgi vesicle transport; cytoplasm to vacuole targeting by the Cvt pathway; and pexophagy. Part of Golgi transport complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human COG3 (component of oligomeric golgi complex 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See COG3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (484788..487193)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein BEM2 Neighboring gene Myg1p Neighboring gene tRNA-Glu Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast GRD20 gene is required for protein sorting in the trans-Golgi network/endosomal system and for polarization of the actin cytoskeleton. Spelbrink RG, et al. Mol Biol Cell, 1999 Dec. PMID 10588657, Free PMC Article
    2. Retrograde transport of the mannosyltransferase Och1p to the early Golgi requires a component of the COG transport complex. Bruinsma P, et al. J Biol Chem, 2004 Sep 17. PMID 15229219
    3. Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway. Shemorry A, et al. Mol Cell, 2013 May 23. PMID 23603116, Free PMC Article
    4. Molecular organization of the COG vesicle tethering complex. Lees JA, et al. Nat Struct Mol Biol, 2010 Nov. PMID 20972446, Free PMC Article
    5. Characterization of Grp1p, a novel cis-Golgi matrix protein. Kim DW. Biochem Biophys Res Commun, 2003 Mar 28. PMID 12646213

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cargo adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasm to vacuole targeting by the Cvt pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pexophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, vesicle recycling within Golgi IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Golgi transport complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Golgi transport complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cis-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Golgi transport complex subunit COG3
    NP_011084.1
    • Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      484788..487193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179047.1 → NP_011084.1  TPA: Golgi transport complex subunit COG3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011084.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM64, P40094
      UniProtKB/TrEMBL
      B5VHT5, G2WD44, N1P557
      Conserved Domains (1) summary
      pfam04136
      Location:86 → 232
      Sec34; Sec34-like family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40094.1

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