U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    SNT2 DNA-binding E3 ubiquitin-protein ligase SNT2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852746, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SNT2
    Official Full Name
    DNA-binding E3 ubiquitin-protein ligase SNT2
    Primary source
    SGD:S000003099
    Locus tag
    YGL131C
    See related
    AllianceGenome:SGD:S000003099; FungiDB:YGL131C; VEuPathDB:YGL131C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ubiquitin protein ligase activity. Involved in cellular response to oxidative stress; histone catabolic process; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of Snt2C complex. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SNT2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (261648..265859, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Pcl10p Neighboring gene Itc1p Neighboring gene mRNA guanylyltransferase Neighboring gene mitochondrial 37S ribosomal protein RSM23

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Predicting functional transcription factor binding through alignment-free and affinity-based analysis of orthologous promoter sequences. Ward LD, et al. Bioinformatics, 2008 Jul 1. PMID 18586710, Free PMC Article
    2. Disruption of six novel Saccharomyces cerevisiae genes reveals that YGL129c is necessary for growth in non-fermentable carbon sources, YGL128c for growth at low or high temperatures and YGL125w is implicated in the biosynthesis of methionine. Tizón B, et al. Yeast, 1999 Jan 30. PMID 10029993
    3. Is transcription factor binding site turnover a sufficient explanation for cis-regulatory sequence divergence? Venkataram S, et al. Genome Biol Evol, 2010. PMID 21068212, Free PMC Article
    4. Transcriptional regulatory code of a eukaryotic genome. Harbison CT, et al. Nature, 2004 Sep 2. PMID 15343339, Free PMC Article
    5. Identifying cooperative transcription factors by combining ChIP-chip data and knockout data. Yang Y, et al. Cell Res, 2010 Nov. PMID 20975739

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that Snt2, Ecm5, and Rpd3 physically associate.
      Title: The yeast Snt2 protein coordinates the transcriptional response to hydrogen peroxide-mediated oxidative stress.
    2. The results highlight the importance of posttranslational histone regulatory mechanisms that employ multiple E3 ubiquitin ligases such as Snt2 to ensure excess histone degradation and thus contribute to the maintenance of genomic stability.
      Title: Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in histone catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in histone catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Lid2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Snt2C complex HDA PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA-binding E3 ubiquitin-protein ligase SNT2
    NP_011384.1
    • Subunit of Snt2C complex, RING finger ubiquitin ligase (E3); physically associates with Ecm5p and Rpd3p; along with Ecm5p, recruits Rpd3p to small number of promoters; colocalizes with Ecm5p, independently of Rpd3p, to promoters of stress response genes upon oxidative stress; involved in ubiquitination, degradation of excess histones; interacts with Ubc4p; role in regulating genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      261648..265859 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180996.1 → NP_011384.1  TPA: DNA-binding E3 ubiquitin-protein ligase SNT2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011384.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU17, P53127
      UniProtKB/TrEMBL
      B3LHJ0, B5VIJ8, C7GX65, N1P9N5
      Conserved Domains (5) summary
      cd04710
      Location:112 → 256
      BAH_fungalPHD; BAH, or Bromo Adjacent Homology domain, as present in fungal proteins containing PHD domains. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of ...
      cd15497
      Location:319 → 366
      PHD1_Snt2p_like; PHD finger 1 found in Saccharomyces cerevisiae SANT domain-containing protein 2 (Snt2p) and similar proteins
      cd15498
      Location:1040 → 1094
      PHD2_Snt2p_like; PHD finger 2 found in Saccharomyces cerevisiae SANT domain-containing protein 2 (Snt2p) and similar proteins
      cd15667
      Location:1108 → 1248
      ePHD_Snt2p_like; Extended PHD finger found in Saccharomyces cerevisiae SANT domain-containing protein 2 (Snt2p) and similar proteins
      pfam00249
      Location:559 → 602
      Myb_DNA-binding; Myb-like DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53127.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools