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    SPO16 Spo16p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856558, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SPO16
    Official Full Name
    Spo16p
    Primary source
    SGD:S000001196
    Locus tag
    YHR153C
    See related
    AllianceGenome:SGD:S000001196; FungiDB:YHR153C; VEuPathDB:YHR153C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA secondary structure binding activity. Involved in several processes, including ascospore formation; positive regulation of protein sumoylation; and synaptonemal complex assembly. Is active in nuclear chromosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SPO16 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (402086..402682, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Mtc6p Neighboring gene Spo12p Neighboring gene Rtt107p Neighboring gene Lam1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. On Spo16 and the coefficient of coincidence. Stahl FW, et al. Genetics, 2009 Jan. PMID 19001288, Free PMC Article
    2. Complementary transcripts from two genes necessary for normal meiosis in the yeast Saccharomyces cerevisiae. Malavasic MJ, et al. Mol Cell Biol, 1990 Jun. PMID 2188099, Free PMC Article
    3. The conserved XPF:ERCC1-like Zip2:Spo16 complex controls meiotic crossover formation through structure-specific DNA binding. Arora K, et al. Nucleic Acids Res, 2019 Mar 18. PMID 30566683, Free PMC Article
    4. Crossover assurance and crossover interference are distinctly regulated by the ZMM proteins during yeast meiosis. Shinohara M, et al. Nat Genet, 2008 Mar. PMID 18297071
    5. The Ecm11-Gmc2 complex promotes synaptonemal complex formation through assembly of transverse filaments in budding yeast. Humphryes N, et al. PLoS Genet, 2013. PMID 23326245, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ur data support a model in which the Zip2:Zip4:Spo16 complex binds and stabilizes early meiotic recombination intermediates, then coordinates additional factors to promote crossover formation and license downstream events including synaptonemal complex assembly.
      Title: The conserved XPF:ERCC1-like Zip2:Spo16 complex controls meiotic crossover formation through structure-specific DNA binding.
    2. Identification of the ZZS (Zip2-Zip4-Spo16) complex which is required for crossover formation.
      Title: A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation.
    3. Spo16 reduces crossing over in the two phases by a similar factor.
      Title: On Spo16 and the coefficient of coincidence.
    4. Interference and assurance in genetic crossovers are mechanistically distinct processes that are separated by mutations in a new ZMM protein from Saccharomyces cerevisiae, Spo16.
      Title: Crossover assurance and crossover interference are distinctly regulated by the ZMM proteins during yeast meiosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA secondary structure binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA secondary structure binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ascospore formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein sumoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of reciprocal meiotic recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptonemal complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptonemal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Spo16p
    NP_012023.1
    • Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      402086..402682 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179284.1 → NP_012023.1  TPA: Spo16p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012023.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLA2, P17122
      UniProtKB/TrEMBL
      B3LSR7, C8Z9V0, N1P4T0
      Conserved Domains (1) summary
      pfam19225
      Location:23 → 196
      Spo16; Spo16 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17122.1

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