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    VHS2 Vhs2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854671, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VHS2
    Official Full Name
    Vhs2p
    Primary source
    SGD:S000001397
    Locus tag
    YIL135C
    See related
    AllianceGenome:SGD:S000001397; FungiDB:YIL135C; VEuPathDB:YIL135C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in cellular bud neck septin ring organization; cellular response to heat; and establishment or maintenance of actin cytoskeleton polarity. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VHS2 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (95065..96375, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Tma108p Neighboring gene Om45p Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vhs2 is a novel regulator of septin dynamics in budding yeast. Cassani C, et al. Cell Cycle, 2014. PMID 24646733, Free PMC Article
    2. Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression. Stirling PC, et al. Mol Biol Cell, 2007 Jun. PMID 17429077, Free PMC Article
    3. Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae. Muñoz I, et al. Yeast, 2003 Jan 30. PMID 12518319
    4. Four novel suppressors of gic1 gic2 and their roles in cytokinesis and polarized cell growth in Saccharomyces cerevisiae. Gandhi M, et al. Genetics, 2006 Oct. PMID 16816427, Free PMC Article
    5. Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening. Mah AS, et al. BMC Biochem, 2005 Oct 21. PMID 16242037, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular bud neck septin ring organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular bud neck septin ring organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to heat IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment or maintenance of actin cytoskeleton polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vhs2p
    NP_012131.1
    • Regulator of septin dynamics; involved in the regulation of septin dynamics at bud neck after mitotic entry, likely by stabilizing septin structure; regulated at post-translational level by cell cycle dependent phosphorylation; likely phosphorylated by Cdc28p and dephosphorylated by Cdc14p before cytokinesis; high-copy suppressor of synthetic lethality of sis2 sit4 double mutant; VHS2 has a paralog, MLF3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      95065..96375 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179483.1 → NP_012131.1  TPA: Vhs2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012131.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVF1, P40463
      UniProtKB/TrEMBL
      A6ZVE0, B3LTY3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40463.1

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