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    DJP1 Djp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854820, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DJP1
    Official Full Name
    Djp1p
    Primary source
    SGD:S000001443
    Locus tag
    YIR004W
    See related
    AllianceGenome:SGD:S000001443; FungiDB:YIR004W; VEuPathDB:YIR004W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ICS1; PAS22
    Summary
    Predicted to enable protein-folding chaperone binding activity. Involved in protein import into peroxisome matrix and protein insertion into mitochondrial outer membrane. Acts upstream of or within protein targeting to mitochondrion. Located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DJP1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (363221..364519)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene 3'-5' DNA helicase Neighboring gene Aim21p Neighboring gene U2 snRNP complex subunit IST3 Neighboring gene Pan1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cytosolic DnaJ-like protein djp1p is involved specifically in peroxisomal protein import. Hettema EH, et al. J Cell Biol, 1998 Jul 27. PMID 9679141, Free PMC Article
    2. The gene ICS3 from the yeast Saccharomyces cerevisiae is involved in copper homeostasis dependent on extracellular pH. Alesso CA, et al. Fungal Genet Biol, 2015 Sep. PMID 26127016
    3. Partial dispensability of Djp1's J domain in peroxisomal protein import in Saccharomyces cerevisiae results from genetic redundancy with another class II J protein, Caj1. Dobriyal N, et al. Cell Stress Chaperones, 2017 May. PMID 28261750, Free PMC Article
    4. An efficient positive selection procedure for the isolation of peroxisomal import and peroxisome assembly mutants of Saccharomyces cerevisiae. Elgersma Y, et al. Genetics, 1993 Nov. PMID 7507454, Free PMC Article
    5. In vitro import experiments with semi-intact cells suggest a role of the Sec61 paralog Ssh1 in mitochondrial biogenesis. Laborenz J, et al. Biol Chem, 2019 Aug 27. PMID 31199753

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tom70 and Djp1 are crucial players in the biogenesis of Mim1.
      Title: The role of Djp1 in import of the mitochondrial protein Mim1 demonstrates specificity between a cochaperone and its substrate protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-folding chaperone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein import into peroxisome matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into peroxisome matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein insertion into mitochondrial outer membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein targeting to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cellular bud HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Djp1p
    NP_012269.1
    • ER-associated chaperone involved in protein targeting; redirects mitochondrial membrane protein precursors to mitochondrial translocation system; required for peroxisomal protein import and involved in peroxisome assembly; facilitates import of Mim1p and Mim2p into the mitochondrial outer membrane; homologous to E. coli DnaJ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      363221..364519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179526.1 → NP_012269.1  TPA: Djp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012269.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVT4, P40564, Q6Q5N6
      UniProtKB/TrEMBL
      A6ZVS2, B3LTK5, C7GJG8, C8ZAQ3, N1P1R8
      Conserved Domains (2) summary
      PRK10767
      Location:7 → 97
      PRK10767; chaperone protein DnaJ; Provisional
      pfam14308
      Location:208 → 422
      DnaJ-X; X-domain of DnaJ-containing
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40564.1

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