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    TGL1 sterol esterase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853717, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TGL1
    Official Full Name
    sterol esterase
    Primary source
    SGD:S000001623
    Locus tag
    YKL140W
    See related
    AllianceGenome:SGD:S000001623; FungiDB:YKL140W; VEuPathDB:YKL140W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YKL5
    Summary
    Enables sterol ester esterase activity. Involved in cellular lipid metabolic process and sterol metabolic process. Located in lipid droplet and membrane. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TGL1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (180779..182425)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Mrp8p Neighboring gene succinate dehydrogenase cytochrome b subunit SDH3 Neighboring gene cyclin-dependent serine/threonine protein kinase CTK1 Neighboring gene Hsk3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The lipid droplet enzyme Tgl1p hydrolyzes both steryl esters and triglycerides in the yeast, Saccharomyces cerevisiae. Jandrositz A, et al. Biochim Biophys Acta, 2005 Jun 15. PMID 15922657
    2. Derivatization-independent cholesterol analysis in crude lipid extracts by liquid chromatography/mass spectrometry: applications to a rabbit model for atherosclerosis. Shui G, et al. J Chromatogr A, 2011 Jul 15. PMID 21621788
    3. Characterization of sterol-ester hydrolase in Saccharomyces cerevisiae. Taketani S, et al. Biochim Biophys Acta, 1978 Jul 7. PMID 28772
    4. Mature lipid droplets are accessible to ER luminal proteins. Mishra S, et al. J Cell Sci, 2016 Oct 15. PMID 27591256
    5. Molecular cloning and physical analysis of an 8.2 kb segment of chromosome XI of Saccharomyces cerevisiae reveals five tightly linked genes. Abraham PR, et al. Yeast, 1992 Mar. PMID 1574929

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this study demonstrates a strong regulation of the two lipid droplet associated steryl ester hydrolases Tgl1p and Yeh1p due to the presence/absence of their host organelle.
      Title: The impact of nonpolar lipids on the regulation of the steryl ester hydrolases Tgl1p and Yeh1p in the yeast Saccharomyces cerevisiae.
    2. A deletion of TGL1 resulted in an increase of the cellular steryl ester content
      Title: The lipid droplet enzyme Tgl1p hydrolyzes both steryl esters and triglycerides in the yeast, Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol ester esterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sterol ester esterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sterol ester esterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sterol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sterol esterase
    NP_012782.1
    • Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      180779..182425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179706.1 → NP_012782.1  TPA: sterol esterase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012782.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX56, P34163
      UniProtKB/TrEMBL
      A6ZZI1, C7GVH6, G2WHP8, N1P2Z2
      Conserved Domains (2) summary
      pfam00561
      Location:106 → 402
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam04083
      Location:66 → 124
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34163.1

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