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    SRP21 signal recognition particle subunit SRP21 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853737, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SRP21
    Official Full Name
    signal recognition particle subunit SRP21
    Primary source
    SGD:S000001605
    Locus tag
    YKL122C
    See related
    AllianceGenome:SGD:S000001605; FungiDB:YKL122C; VEuPathDB:YKL122C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA binding activity. Involved in SRP-dependent cotranslational protein targeting to membrane. Located in nucleus. Part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SRP21 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (212495..212998, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene rDNA-binding RNA polymerase I transcriptional factor Neighboring gene Ssh4p Neighboring gene Dgr2p Neighboring gene Oac1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Misactivation of multiple starvation responses in yeast by loss of tRNA modifications. Bruch A, et al. Nucleic Acids Res, 2020 Jul 27. PMID 32484543, Free PMC Article
    2. Elongation arrest is a physiologically important function of signal recognition particle. Mason N, et al. EMBO J, 2000 Aug 1. PMID 10921896, Free PMC Article
    3. Nuclear export of yeast signal recognition particle lacking Srp54p by the Xpo1p/Crm1p NES-dependent pathway. Ciufo LF, et al. Curr Biol, 2000 Oct 19. PMID 11069106
    4. Subunits of the Saccharomyces cerevisiae signal recognition particle required for its functional expression. Brown JD, et al. EMBO J, 1994 Sep 15. PMID 7925282, Free PMC Article
    5. eIF5A has a function in the cotranslational translocation of proteins into the ER. Rossi D, et al. Amino Acids, 2014 Mar. PMID 24306454

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SRP-dependent cotranslational protein targeting to membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in SRP-dependent cotranslational protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal recognition particle IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of signal recognition particle, endoplasmic reticulum targeting IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    signal recognition particle subunit SRP21
    NP_012800.1
    • Subunit of the signal recognition particle (SRP); SRP functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      212495..212998 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179688.1 → NP_012800.1  TPA: signal recognition particle subunit SRP21 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012800.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXG8, P32342
      UniProtKB/TrEMBL
      A6ZZJ7, B3LQX6, C8ZC53, G2WHR4, N1NZR1
      Conserved Domains (1) summary
      pfam05486
      Location:3 → 78
      SRP9-21; Signal recognition particle 9 kDa protein (SRP9)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32342.3

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