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    DAL80 Dal80p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853904, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DAL80
    Official Full Name
    Dal80p
    Primary source
    SGD:S000001742
    Locus tag
    YKR034W
    See related
    AllianceGenome:SGD:S000001742; FungiDB:YKR034W; VEuPathDB:YKR034W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    UGA43
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and nitrogen catabolite repression of transcription. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DAL80 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (506898..507707)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene phospholipase D Neighboring gene uncharacterized protein Neighboring gene Did2p Neighboring gene Caf4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The UGA43 negative regulatory gene of Saccharomyces cerevisiae contains both a GATA-1 type zinc finger and a putative leucine zipper. Coornaert D, et al. Curr Genet, 1992 Apr. PMID 1525858
    2. Expression of the DAL80 gene, whose product is homologous to the GATA factors and is a negative regulator of multiple nitrogen catabolic genes in Saccharomyces cerevisiae, is sensitive to nitrogen catabolite repression. Cunningham TS, et al. Mol Cell Biol, 1992 May. PMID 1569960, Free PMC Article
    3. Green fluorescent protein-Dal80p illuminates up to 16 distinct foci that colocalize with and exhibit the same behavior as chromosomal DNA proceeding through the cell cycle of Saccharomyces cerevisiae. Distler M, et al. J Bacteriol, 2001 Aug. PMID 11443099, Free PMC Article
    4. Chinese Yellow Rice Wine Processing with Reduced Ethyl Carbamate Formation by Deleting Transcriptional Regulator Dal80p in Saccharomyces cerevisiae. Wei T, et al. Molecules, 2020 Aug 6. PMID 32781689, Free PMC Article
    5. The UGA4 UASNTR site required for GLN3-dependent transcriptional activation also mediates DAL80-responsive regulation and DAL80 protein binding in Saccharomyces cerevisiae. Cunningham TS, et al. J Bacteriol, 1994 Aug. PMID 8045902, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nitrate assimilation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nitrogen catabolite repression of transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dal80p
    NP_012959.1
    • Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      506898..507707
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179824.1 → NP_012959.1  TPA: Dal80p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012959.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX97, P26343
      UniProtKB/TrEMBL
      A6ZZZ6, B3LRB5, B5VMI1, C8ZCJ8, G2WI64, N1P0H4
      Conserved Domains (1) summary
      COG5641
      Location:1 → 269
      GAT1; GATA Zn-finger-containing transcription factor [Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26343.1

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