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    SHB17 sedoheptulose-bisphosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853917, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SHB17
    Official Full Name
    sedoheptulose-bisphosphatase
    Primary source
    SGD:S000001751
    Locus tag
    YKR043C
    See related
    AllianceGenome:SGD:S000001751; FungiDB:YKR043C; VEuPathDB:YKR043C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables sedoheptulose-bisphosphatase activity. Involved in ribose phosphate biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SHB17 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (520897..521712, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene SUN family protein UTH1 Neighboring gene Uip5p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and activity of the metal-independent fructose-1,6-bisphosphatase YK23 from Saccharomyces cerevisiae. Kuznetsova E, et al. J Biol Chem, 2010 Jul 2. PMID 20427268, Free PMC Article
    2. Riboneogenesis in yeast. Clasquin MF, et al. Cell, 2011 Jun 10. PMID 21663798, Free PMC Article
    3. Promiscuous phosphoketolase and metabolic rewiring enables novel non-oxidative glycolysis in yeast for high-yield production of acetyl-CoA derived products. Hellgren J, et al. Metab Eng, 2020 Nov. PMID 32911054
    4. Capturing the Asc1p/Receptor for Activated C Kinase 1 (RACK1) Microenvironment at the Head Region of the 40S Ribosome with Quantitative BioID in Yeast. Opitz N, et al. Mol Cell Proteomics, 2017 Dec. PMID 28982715, Free PMC Article
    5. The zinc-finger transcription factor Sfp1 imprints specific classes of mRNAs and links their synthesis to cytoplasmic decay. Kelbert M, et al. Elife, 2024 Oct 2. PMID 39356734, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sedoheptulose-bisphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sedoheptulose-bisphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sedoheptulose-bisphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sedoheptulose-bisphosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ribose phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribose phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribose phosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sedoheptulose-bisphosphatase
    NP_012969.1
    • Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      520897..521712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179833.1 → NP_012969.1  TPA: sedoheptulose-bisphosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012969.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXA5, P36136
      UniProtKB/TrEMBL
      A7A004, B3LRC3, C8ZCK8, G2WI72, N1P2P8
      Conserved Domains (1) summary
      pfam00300
      Location:9 → 192
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36136.1

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