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    PEX13 peroxin PEX13 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850888, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PEX13
    Official Full Name
    peroxin PEX13
    Primary source
    SGD:S000004181
    Locus tag
    YLR191W
    See related
    AllianceGenome:SGD:S000004181; FungiDB:YLR191W; VEuPathDB:YLR191W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PAS20
    Summary
    Enables protein-macromolecule adaptor activity. Involved in protein import into peroxisome matrix, docking. Located in peroxisomal membrane. Part of peroxisomal importomer complex. Used to study peroxisomal disease. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 11B; peroxisomal disease; and peroxisome biogenesis disorder 11A. Orthologous to human PEX13 (peroxisomal biogenesis factor 13). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PEX13 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (537272..538432)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene sterol 3-beta-glucosyltransferase Neighboring gene Mmr1p Neighboring gene translation initiation factor eIF3 core subunit j Neighboring gene Ups1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Peroxisome biogenesis disorders: identification of a new complementation group distinct from peroxisome-deficient CHO mutants and not complemented by human PEX 13. Shimozawa N, et al. Biochem Biophys Res Commun, 1998 Feb 13. PMID 9480815
    2. The ScPex13p SH3 domain exposes two distinct binding sites for Pex5p and Pex14p. Pires JR, et al. J Mol Biol, 2003 Mar 7. PMID 12595255
    3. The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins. Elgersma Y, et al. J Cell Biol, 1996 Oct. PMID 8858166, Free PMC Article
    4. An efficient positive selection procedure for the isolation of peroxisomal import and peroxisome assembly mutants of Saccharomyces cerevisiae. Elgersma Y, et al. Genetics, 1993 Nov. PMID 7507454, Free PMC Article
    5. Hansenula polymorpha Pex19p is essential for the formation of functional peroxisomal membranes. Otzen M, et al. J Biol Chem, 2004 Apr 30. PMID 14981078

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data demonstrate that Pex8p is capable to interact with the PTS2-receptor Pex7p and the docking complex component Pex13p with its C-terminal SH3-domain providing the binding site.
      Title: Targeting of Pex8p to the peroxisomal importomer.
    2. A novel Pex-14 binding site in Pex13 was identified, which is essential for peroxisomal protein import.
      Title: Identification of a novel, intraperoxisomal pex14-binding site in pex13: association of pex13 with the docking complex is essential for peroxisomal matrix protein import.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein import into peroxisome matrix, docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into peroxisome matrix, docking IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into peroxisome matrix, docking IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein import into peroxisome matrix, docking IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of peroxisomal importomer complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of peroxisomal importomer complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    peroxin PEX13
    NP_013292.1
    • Peroxisomal importomer complex component; integral peroxisomal membrane protein required for docking and translocation of peroxisomal matrix proteins; interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p; forms a complex with Pex14p and Pex17p; human homolog PEX13 complements yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      537272..538432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182078.1 → NP_013292.1  TPA: peroxin PEX13 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013292.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYJ4, P80667
      UniProtKB/TrEMBL
      A7A181, B5VNB0, C7GIX8, N1P6S5
      Conserved Domains (2) summary
      cd11771
      Location:310 → 369
      SH3_Pex13p_fungal; Src Homology 3 domain of fungal peroxisomal membrane protein Pex13p
      pfam04088
      Location:140 → 283
      Peroxin-13_N; Peroxin 13, N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P80667.1

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