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    GYL1 Gyl1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855230, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GYL1
    Official Full Name
    Gyl1p
    Primary source
    SGD:S000004804
    Locus tag
    YMR192W
    See related
    AllianceGenome:SGD:S000004804; FungiDB:YMR192W; VEuPathDB:YMR192W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    APP2
    Summary
    Predicted to enable GTPase activator activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and regulation of exocytosis. Located in several cellular components, including Golgi-associated vesicle; cellular bud tip; and incipient cellular bud site. Orthologous to several human genes including EVI5 (ecotropic viral integration site 5) and EVI5L (ecotropic viral integration site 5 like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GYL1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (647118..649280)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ATP-dependent DNA helicase SGS1 Neighboring gene Spg5p Neighboring gene mitochondrial 54S ribosomal protein YmL24/YmL14 Neighboring gene ribosomal 60S subunit protein L36A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interdependence of the Ypt/RabGAP Gyp5p and Gyl1p for recruitment to the sites of polarized growth. Chesneau L, et al. Traffic, 2008 Apr. PMID 18182006
    2. Gyp5p and Gyl1p are involved in the control of polarized exocytosis in budding yeast. Chesneau L, et al. J Cell Sci, 2004 Sep 15. PMID 15331637
    3. Three members of the yeast N-BAR proteins family form heterogeneous lattices in vivo and interact differentially with two RabGAP proteins. Prigent M, et al. Sci Rep, 2020 Feb 3. PMID 32015451, Free PMC Article
    4. A novel link between a rab GTPase and Rvs proteins: the yeast amphiphysin homologues. Talarek N, et al. Cell Biochem Funct, 2005 Jul-Aug. PMID 15473003
    5. Interaction of the Saccharomyces cerevisiae cortical actin patch protein Rvs167p with proteins involved in ER to Golgi vesicle trafficking. Friesen H, et al. Genetics, 2005 Jun. PMID 15802519, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In gyp5Deltagyl1Delta cells, Rvs167p is not correctly localized to the small-bud tip.
      Title: The RabGAP proteins Gyp5p and Gyl1p recruit the BAR domain protein Rvs167p for polarized exocytosis.
    2. Results describe the interaction between Gyp5p and Gyl1p as well as the mechanism of their localization to the sites of polarized growth, and show that purified recombinant Gyp5p and Gyl1p interact directly in vitro.
      Title: Interdependence of the Ypt/RabGAP Gyp5p and Gyl1p for recruitment to the sites of polarized growth.
    3. These data suggest that Gyp5p and Gyl1p are involved in control of polarized exocytosis.
      Title: Gyp5p and Gyl1p are involved in the control of polarized exocytosis in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of exocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of exocytosis IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi-associated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud HDA PubMed 
    located_in cellular bud IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud tip HDA PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in site of polarized growth IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Gyl1p
    NP_013917.1
    • Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress; GYL1 has a paralog, GYP5, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      647118..649280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182698.1 → NP_013917.1  TPA: Gyl1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013917.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W016, Q04322
      UniProtKB/TrEMBL
      B3LM79, C7GRF9, N1NYK3
      Conserved Domains (1) summary
      COG5210
      Location:27 → 569
      COG5210; GTPase-activating protein [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04322.1

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