CUE5 ubiquitin-binding protein CUE5 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: CUE5
Official Full Name: ubiquitin-binding protein CUE5
Primary source: SGD:S000005568
Locus tag: YOR042W
See related: AllianceGenome:SGD:S000005568; FungiDB:YOR042W; VEuPathDB:YOR042W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables polyubiquitin modification-dependent protein binding activity; protein-macromolecule adaptor activity; and ubiquitin binding activity. Involved in cellular response to nitrogen starvation and ubiquitin-dependent protein catabolic process. Located in cytoplasm. Used to study neurodegenerative disease. Orthologous to human TOLLIP (toll interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables K48-linked polyubiquitin modification-dependent protein binding	IDA Inferred from Direct Assay more info	PubMed
enables K63-linked polyubiquitin modification-dependent protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-macromolecule adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nitrogen starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

NP_014685.1

Selective autophagy receptor involved in aggrephagy and proteaphagy; ubiquitin (Ub)-binding protein that functions as a Ub-Atg8p adaptor in Ub-dependent autophagy; serves as a proteaphagy receptor for inactivate 26S proteasomes; contains a CUE domain that binds K48-and K63-linked Ub chains and monoubiquitin, facilitating intramolecular monoubiquitination; human TOLLIP is a functional CUE-domain homolog, that complements a null mutant, rescuing the hypersensitivity of the null mutant to Htt-96Q

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