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    NRT1 nicotinamide riboside transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854237, updated on 9-Dec-2024

    Summary

    Official Symbol
    NRT1
    Official Full Name
    nicotinamide riboside transporter
    Primary source
    SGD:S000005597
    Locus tag
    YOR071C
    See related
    AllianceGenome:SGD:S000005597; FungiDB:YOR071C; VEuPathDB:YOR071C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    THI71; YOR29-22
    Summary
    Enables 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity and nicotinamide riboside transmembrane transporter activity. Involved in 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport; nicotinamide riboside transport; and thiamine transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See NRT1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (459480..461276, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Vam10p Neighboring gene sorting nexin 1 Neighboring gene GTPase-activating protein GYP1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tRNA-Pro

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nicotinamide riboside transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in nicotinamide riboside transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nucleobase transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in thiamine transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    nicotinamide riboside transporter
    NP_014714.1
    • High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; major transporter for 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine) uptake; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      459480..461276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183490.1NP_014714.1  TPA: nicotinamide riboside transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014714.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2D4, O00029, Q08485
      UniProtKB/TrEMBL
      C8ZI32, G2WMU9
      Conserved Domains (1) summary
      cd11482
      Location:27505
      SLC-NCS1sbd_NRT1-like; nucleobase-cation-symport-1 (NCS1) transporter NRT1-like; solute-binding domain