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    SGO1 Sgo1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854240, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SGO1
    Official Full Name
    Sgo1p
    Primary source
    SGD:S000005599
    Locus tag
    YOR073W
    See related
    AllianceGenome:SGD:S000005599; FungiDB:YOR073W; VEuPathDB:YOR073W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YOR29-24
    Summary
    Involved in several processes, including chromosome organization; meiotic sister chromatid separation; and regulation of chromosome organization. Located in kinetochore. Is active in chromosome, centromeric region. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SGO1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (464771..466543)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tRNA-Pro Neighboring gene thymidylate synthase Neighboring gene Ufe1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Persistent mechanical linkage between sister chromatids throughout anaphase. Harrison BD, et al. Chromosoma, 2009 Oct. PMID 19603176, Free PMC Article
    2. Shugoshin biases chromosomes for biorientation through condensin recruitment to the pericentromere. Verzijlbergen KF, et al. Elife, 2014. PMID 24497542, Free PMC Article
    3. Sgo1 is required for co-segregation of sister chromatids during achiasmate meiosis I. Dudas A, et al. Cell Cycle, 2011 Mar 15. PMID 21330786, Free PMC Article
    4. The many faces of shugoshin, the "guardian spirit," in chromosome segregation. Macy B, et al. Cell Cycle, 2009 Jan 1. PMID 19106605
    5. Tripartite Chromatin Localization of Budding Yeast Shugoshin Involves Higher-Ordered Architecture of Mitotic Chromosomes. Deng X, et al. G3 (Bethesda), 2018 Aug 30. PMID 30002083, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SUMOylation stabilizes sister kinetochore biorientation to allow timely anaphase.
      Title: SUMOylation stabilizes sister kinetochore biorientation to allow timely anaphase.
    2. Phospho-regulation of the Shugoshin - Condensin interaction at the centromere in budding yeast.
      Title: Phospho-regulation of the Shugoshin - Condensin interaction at the centromere in budding yeast.
    3. The TSM-Sgo1p-cohesin triad is therefore at the center stage of higher-ordered chromatin architecture for error-free segregation.
      Title: Tripartite Chromatin Localization of Budding Yeast Shugoshin Involves Higher-Ordered Architecture of Mitotic Chromosomes.
    4. sgo1 mutants with abolished binding to H2A or PP2A(Rts1) displayed premature SAC silencing.
      Title: Premature Silencing of the Spindle Assembly Checkpoint Is Prevented by the Bub1-H2A-Sgo1-PP2A Axis in Saccharomyces cerevisiae.
    5. Sgo1 operates as a multifunctional hub that coordinates two centromeric functions essential for correct chromosome segregation.
      Title: Sgo1 regulates both condensin and Ipl1/Aurora B to promote chromosome biorientation.
    6. budding yeast shugoshin Sgo1 dissociates from the pericentromere reversibly in response to tension
      Title: Tension-dependent removal of pericentromeric shugoshin is an indicator of sister chromosome biorientation.
    7. Bub1 and Sgo1 act as a rheostat to regulate the chromatin spring and maintain force balance. Through histone H2A S121 phosphorylation and recruitment of Sgo1, Bub1 kinase softens the chromatin spring in response to changes in microtubule dynamics.
      Title: Bub1 kinase and Sgo1 modulate pericentric chromatin in response to altered microtubule dynamics.
    8. found that Sgo1 overexpression rescues defects caused by metaphase inactivation of Mps1 and that Mps1 is required for Sgo1 localization to the kinetochore
      Title: Bub1, Sgo1, and Mps1 mediate a distinct pathway for chromosome biorientation in budding yeast.
    9. Sister kinetochores are frequently bi-oriented in the absence of chiasmata and that Sgo1 prevents equational segregation of sister chromatids during achiasmate meiosis I.
      Title: Sgo1 is required for co-segregation of sister chromatids during achiasmate meiosis I.
    10. Report structure and function of the PP2A-shugoshin interaction.
      Title: Structure and function of the PP2A-shugoshin interaction.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centromere complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of protein localization to chromosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in kinetochore organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in kinetochore organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of meiotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic sister chromatid separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of maintenance of meiotic sister chromatid cohesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of maintenance of meiotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sister chromatid biorientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed chromosome, centromeric region IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sgo1p
    NP_014716.1
    • Component of the spindle checkpoint; involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability; recruits condensin to the pericentric region of chromosomes during meiosis; dissociates from pericentromeres when sister kinetochores are under tension

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      464771..466543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183492.1 → NP_014716.1  TPA: Sgo1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014716.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2D6, O00031, Q08490
      UniProtKB/TrEMBL
      C7GT42
      Conserved Domains (2) summary
      pfam07557
      Location:366 → 390
      Shugoshin_C; Shugoshin C-terminus
      pfam07558
      Location:43 → 87
      Shugoshin_N; Shugoshin N-terminal coiled-coil region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08490.1

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