TBF1 Tbf1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: TBF1
Official Full Name: Tbf1p
Primary source: SGD:S000006049
Locus tag: YPL128C
See related: AllianceGenome:SGD:S000006049; FungiDB:YPL128C; VEuPathDB:YPL128C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: LPI16
Summary: Enables DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in negative regulation of telomere maintenance via telomerase; snoRNA transcription by RNA polymerase II; and telomere maintenance via telomere lengthening. Acts upstream of or within chromatin remodeling. Located in chromosome, telomeric region. [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

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Abf1, Reb1, and Tbf1 control ribosome biogenesis gene expression in budding yeast.
Title: Abf1 and other general regulatory factors control ribosome biogenesis gene expression in budding yeast.
Tbf1 and Vid22 promote resection and non-homologous end joining of DNA double-strand break ends.
Title: Tbf1 and Vid22 promote resection and non-homologous end joining of DNA double-strand break ends.
These data support a model in which Tbf1 and Rap1 collaborate to maintain genomic stability of short telomeres.
Title: Subtelomere-binding protein Tbf1 and telomere-binding protein Rap1 collaborate to inhibit localization of the Mre11 complex to DNA ends in budding yeast.
Tbf1 capping of DNA is an evolved function.
Title: DNA-end capping by the budding yeast transcription factor and subtelomeric binding protein Tbf1.
Fission and budding yeast Tbf1 proteins have diverged significantly in their functions.
Title: Functional differentiation of tbf1 orthologues in fission and budding yeasts.
Data show that Tel1 kinase and subtelomere-bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast.
Title: Tel1 kinase and subtelomere-bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin insulator sequence binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables telomeric DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables telomeric DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin remodeling	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of telomere maintenance via telomerase	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in snoRNA transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in snoRNA transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance via telomere lengthening	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance via telomere lengthening	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_015197.1

Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation; involved in nucleosome displacement during double-strand break repair

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