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    MEP3 ammonium permease MEP3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856260, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MEP3
    Official Full Name
    ammonium permease MEP3
    Primary source
    SGD:S000006342
    Locus tag
    YPR138C
    See related
    AllianceGenome:SGD:S000006342; FungiDB:YPR138C; VEuPathDB:YPR138C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ammonium channel activity. Involved in ammonium transmembrane transport and nitrogen utilization. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MEP3 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (810984..812453, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene gag-pol fusion protein Neighboring gene gag protein Neighboring gene tRNA-Asn Neighboring gene lysophosphatidic acid acyltransferase LOA1 Neighboring gene lysophosphatidylcholine acyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Impact of ammonium permeases mepA, mepB, and mepC on nitrogen-regulated secondary metabolism in Fusarium fujikuroi. Teichert S, et al. Eukaryot Cell, 2008 Feb. PMID 18083831, Free PMC Article
    2. Nitrogen isotope signature evidences ammonium deprotonation as a common transport mechanism for the AMT-Mep-Rh protein superfamily. Ariz I, et al. Sci Adv, 2018 Sep. PMID 30214933, Free PMC Article
    3. Ammonium permease-based sensing mechanism for rapid ammonium activation of the protein kinase A pathway in yeast. Van Nuland A, et al. Mol Microbiol, 2006 Mar. PMID 16468990
    4. Isolation and characterization from pathogenic fungi of genes encoding ammonium permeases and their roles in dimorphism. Smith DG, et al. Mol Microbiol, 2003 Oct. PMID 14507379
    5. Homo- and hetero-oligomerization of ammonium transporter-1 NH4 uniporters. Ludewig U, et al. J Biol Chem, 2003 Nov 14. PMID 12952951

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ammonium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ammonium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ammonium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ammonium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ammonium transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ammonium transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ammonium transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nitrogen utilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ammonium permease MEP3
    NP_015464.1
    • Ammonium permease of high capacity and low affinity; belongs to Mep-Amt-Rh family of well-conserved ammonium (NH4+) transporters that includes the human Rh factors; expression is under the nitrogen catabolite repression regulation ammonia permease activity regulated by TORC1 effectors, Npr1p and Par32p; MEP3 has a paralog, MEP1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      810984..812453 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184235.1 → NP_015464.1  TPA: ammonium permease MEP3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015464.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4D6, P53390, Q6B2F5
      UniProtKB/TrEMBL
      A6ZX15, B3LK99, B5VTS5, C7GLJ8, C8ZJG1, N1NW55
      Conserved Domains (1) summary
      COG0004
      Location:13 → 430
      AmtB; Ammonia channel protein AmtB [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53390.1

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